3u4c
From Proteopedia
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| - | {{STRUCTURE_3u4c| PDB=3u4c | SCENE= }} | ||
| - | ===Crystal structure of YwfH, NADPH dependent reductase involved in Bacilysin biosynthesis=== | ||
| - | {{ABSTRACT_PUBMED_23519407}} | ||
| - | == | + | ==Crystal structure of YwfH, NADPH dependent reductase involved in Bacilysin biosynthesis== |
| - | [[ | + | <StructureSection load='3u4c' size='340' side='right'caption='[[3u4c]], [[Resolution|resolution]] 2.03Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[3u4c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U4C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U4C FirstGlance]. <br> |
| - | [[3u4c]] is a 1 chain structure with sequence from [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u4c OCA], [https://pdbe.org/3u4c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u4c RCSB], [https://www.ebi.ac.uk/pdbsum/3u4c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u4c ProSAT]</span></td></tr> |
| - | < | + | </table> |
| - | [[ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/BACG_BACSU BACG_BACSU] Along with the bacABCDEF operon, BacG is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase (PubMed:20052993). BacG catalyzes the stereoselective reduction of exocyclic-delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP), adding a pro-S hydride equivalent to C4 position to yield tetrahydro-hydroxyphenylpyruvate (H4HPP) (PubMed:22765234, PubMed:23519407). Although the 3Z,7R-ex-H2HPP isomer is kinetically disfavored by BacB and produced in a smaller quantity than 3E,7R-ex-H2HPP, it is the preferred substrate for the conjugate reduction reaction of BacG (PubMed:22765234, PubMed:23519407).<ref>PMID:20052993</ref> <ref>PMID:22765234</ref> <ref>PMID:23519407</ref> | |
| - | [ | + | == References == |
| - | [ | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Bacillus subtilis]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| + | [[Category: Gopal B]] | ||
| + | [[Category: Rajavel M]] | ||
Current revision
Crystal structure of YwfH, NADPH dependent reductase involved in Bacilysin biosynthesis
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