4oq5

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{{STRUCTURE_4oq5| PDB=4oq5 | SCENE= }}
 
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===Crystal Structure of Human MCL-1 Bound to Inhibitor 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid===
 
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{{ABSTRACT_PUBMED_24582986}}
 
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==Function==
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==Crystal Structure of Human MCL-1 Bound to Inhibitor 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid==
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[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
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<StructureSection load='4oq5' size='340' side='right'caption='[[4oq5]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4oq5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OQ5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.86&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2UU:4-(4-METHYLNAPHTHALEN-1-YL)-2-{[(4-PHENOXYPHENYL)SULFONYL]AMINO}BENZOIC+ACID'>2UU</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oq5 OCA], [https://pdbe.org/4oq5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oq5 RCSB], [https://www.ebi.ac.uk/pdbsum/4oq5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oq5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
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==About this Structure==
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==See Also==
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[[4oq5]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQ5 OCA].
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:024582986</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Kunzer, A R.]]
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</StructureSection>
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[[Category: Park, C.]]
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[[Category: Homo sapiens]]
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[[Category: Petros, A M.]]
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[[Category: Large Structures]]
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[[Category: Song, D.]]
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[[Category: Kunzer AR]]
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[[Category: Souers, A J.]]
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[[Category: Park C]]
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[[Category: Sun, C.]]
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[[Category: Petros AM]]
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[[Category: Swann, S L.]]
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[[Category: Song D]]
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[[Category: Swinger, K.]]
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[[Category: Souers AJ]]
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[[Category: Wendt, M D.]]
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[[Category: Sun C]]
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[[Category: Zhang, H.]]
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[[Category: Swann SL]]
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[[Category: Apoptosis-inhibitor complex]]
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[[Category: Swinger K]]
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[[Category: Wendt MD]]
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[[Category: Zhang H]]

Current revision

Crystal Structure of Human MCL-1 Bound to Inhibitor 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid

PDB ID 4oq5

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