4j7n

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{{STRUCTURE_4j7n| PDB=4j7n | SCENE= }}
 
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===Crystal structure of mouse DXO in complex with M7GPPPG cap===
 
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{{ABSTRACT_PUBMED_23523372}}
 
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==Function==
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==Crystal structure of mouse DXO in complex with M7GPPPG cap==
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[[http://www.uniprot.org/uniprot/DOM3Z_MOUSE DOM3Z_MOUSE]] May possess pyrophosphohydrolase activity towards 5' triphosphorylated RNA (By similarity).
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<StructureSection load='4j7n' size='340' side='right'caption='[[4j7n]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4j7n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J7N FirstGlance]. <br>
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[[4j7n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7N OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9MG:9-METHYLGUANINE'>9MG</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GTG:7-METHYL-GUANOSINE-5-TRIPHOSPHATE-5-GUANOSINE'>GTG</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7n OCA], [https://pdbe.org/4j7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j7n RCSB], [https://www.ebi.ac.uk/pdbsum/4j7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j7n ProSAT]</span></td></tr>
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<ref group="xtra">PMID:023523372</ref><references group="xtra"/><references/>
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</table>
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[[Category: Lk3 transgenic mice]]
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== Function ==
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[[Category: Chang, J H.]]
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[https://www.uniprot.org/uniprot/DXO_MOUSE DXO_MOUSE] Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates.<ref>PMID:23523372</ref>
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[[Category: Kilic, T.]]
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== References ==
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[[Category: Tong, L.]]
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<references/>
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[[Category: 5'-3' exoribonuclease]]
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__TOC__
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[[Category: Decapping]]
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</StructureSection>
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[[Category: Hydrolase]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Chang JH]]
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[[Category: Kilic T]]
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[[Category: Tong L]]

Current revision

Crystal structure of mouse DXO in complex with M7GPPPG cap

PDB ID 4j7n

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