4cge
From Proteopedia
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| - | {{STRUCTURE_4cge| PDB=4cge | SCENE= }} | ||
| - | ===Crystal structure of Mycobacterium tuberculosis Resuscitation promoting factor E=== | ||
| - | {{ABSTRACT_PUBMED_24452911}} | ||
| - | == | + | ==Crystal structure of Mycobacterium tuberculosis Resuscitation promoting factor E== |
| - | [[http://www.uniprot.org/uniprot/RPFE_MYCTU RPFE_MYCTU]] Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little to no effect on actively-growing cells. PG fragments could either directly activate the resuscitation pathway of dormant bacteria or serve as a substrate for endogenous Rpf, resulting in low molecular weight products with resuscitation activity.<ref>PMID:12410821</ref> Stimulates growth of stationary phase M.bovis (a slow-growing Mycobacterium), reduces the lag phase of diluted fast-growers M.smegmatis and Micrococcus luteus. Sequential gene disruption indicates RpfB and RpfE are higher than RpfD and RpfC in functional hierarchy.<ref>PMID:12410821</ref> | + | <StructureSection load='4cge' size='340' side='right'caption='[[4cge]], [[Resolution|resolution]] 2.76Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[4cge]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CGE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CGE FirstGlance]. <br> |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cge OCA], [https://pdbe.org/4cge PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cge RCSB], [https://www.ebi.ac.uk/pdbsum/4cge PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cge ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [[https://www.uniprot.org/uniprot/RPFE_MYCTU RPFE_MYCTU]] Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little to no effect on actively-growing cells. PG fragments could either directly activate the resuscitation pathway of dormant bacteria or serve as a substrate for endogenous Rpf, resulting in low molecular weight products with resuscitation activity.<ref>PMID:12410821</ref> Stimulates growth of stationary phase M.bovis (a slow-growing Mycobacterium), reduces the lag phase of diluted fast-growers M.smegmatis and Micrococcus luteus. Sequential gene disruption indicates RpfB and RpfE are higher than RpfD and RpfC in functional hierarchy.<ref>PMID:12410821</ref> | |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| + | [[Category: Mycobacterium tuberculosis]] | ||
| + | [[Category: Alber T]] | ||
| + | [[Category: Mavrici D]] | ||
| + | [[Category: Prigozhin DM]] | ||
Current revision
Crystal structure of Mycobacterium tuberculosis Resuscitation promoting factor E
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