Hemagglutinin-esterase

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{{STRUCTURE_3i1l| PDB=3i1l | SIZE=400| SCENE= |right|CAPTION=Porcine torovirus hemagglutinin-esterase glycoprotein complex with receptor [[3i1l]]}}
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<StructureSection load='' size='350' side='right' scene='48/484851/Cv/1' caption='Pig torovirus glycosylated hemagglutinin-esterase glycoprotein complex with receptor and acetate [[3i1l]]'>
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== Function ==
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'''Hemagglutinin-esterase''' (HE) is a glycoprotein of the envelopes of some viruses. HE recognizes the host cell surface receptor - a sialic acid derivative. The esterase region of the HE is responsible for the destruction of the receptor<ref>PMID:16575523</ref>.
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'''Hemagglutinin-esterase''' (HE) is a glycoprotein of the envelopes of some viruses. HE recognizes the host cell surface receptor. The esterase region of the HE is responsible for the destruction of the receptor. The HE is a trimer and each monomer contains 3 domains: the membrane fusion domain, the esterase domain and the receptor-binding domain.
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==3D structures of hemagglutinin-esterase==
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== Structural highlights ==
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The biological assmebly of HE is a <scene name='48/484851/Cv/7'>dimer</scene> and each monomer contains <scene name='48/484851/Cv/8'>3 domains: the membrane fusion domain, the esterase domain and the receptor-binding domain</scene>. The receptor binding site of HE is located at five exposed surface loops. <scene name='48/484851/Cv/9'>Acetylated sialic acid binding site</scene>. HE contains a <scene name='48/484851/Cv/10'>conserved metal-binding site</scene><ref>PMID:22291594</ref>.
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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==3D structures of hemagglutinin-esterase==
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[[Hemagglutinin-esterase 3D structures]]
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[[3cl4]] – bHE – bovine<br />
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</StructureSection>
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[[3cl5]] – bHE (mutant) + sialic acid derivative<br />
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[[3i1k]] – PtHE (mutant) – porcine torovirus<br />
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[[3i1l]] – PtHE (mutant) + receptor<br />
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[[3i26]] – BtHE – bovine torovirus<br />
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[[3i27]] – BtHE + receptor<br />
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[[4c7l]] – mhvHE (mutant) – murine hepatitis virus<br />
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[[4c7w]] – mhvHE (mutant) + sialic acid<br />
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Pig torovirus glycosylated hemagglutinin-esterase glycoprotein complex with receptor and acetate 3i1l

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References

  1. ↑ de Groot RJ. Structure, function and evolution of the hemagglutinin-esterase proteins of corona- and toroviruses. Glycoconj J. 2006 Feb;23(1-2):59-72. PMID:16575523 doi:http://dx.doi.org/10.1007/s10719-006-5438-8
  2. ↑ Langereis MA, Zeng Q, Heesters BA, Huizinga EG, de Groot RJ. The murine coronavirus hemagglutinin-esterase receptor-binding site: a major shift in ligand specificity through modest changes in architecture. PLoS Pathog. 2012 Jan;8(1):e1002492. doi: 10.1371/journal.ppat.1002492. Epub 2012, Jan 26. PMID:22291594 doi:http://dx.doi.org/10.1371/journal.ppat.1002492

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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