4crf

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'''Unreleased structure'''
 
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The entry 4crf is ON HOLD until Paper Publication
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==Creating novel F1 inhibitors through fragment based lead generation and structure aided drug design==
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<StructureSection load='4crf' size='340' side='right'caption='[[4crf]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4crf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CRF FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=R9B:N-[(1S)-1-BENZYL-2-[(6-CHLORO-2-OXO-1H-QUINOLIN-4-YL)METHYLAMINO]-2-OXO-ETHYL]-4-HYDROXY-2-OXO-1H-QUINOLINE-6-CARBO'>R9B</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4crf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4crf OCA], [https://pdbe.org/4crf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4crf RCSB], [https://www.ebi.ac.uk/pdbsum/4crf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4crf ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN] Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:[https://omim.org/entry/612416 612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.<ref>PMID:2813350</ref> <ref>PMID:1547342</ref> <ref>PMID:7888672</ref> <ref>PMID:7669672</ref> <ref>PMID:9401068</ref> <ref>PMID:9787168</ref> <ref>PMID:10027710</ref> <ref>PMID:10606881</ref> <ref>PMID:11895778</ref> <ref>PMID:15026311</ref> <ref>PMID:15180874</ref> <ref>PMID:15953011</ref> <ref>PMID:16607084</ref> <ref>PMID:18005151</ref> <ref>PMID:21668437</ref> <ref>PMID:21457405</ref> <ref>PMID:22016685</ref> <ref>PMID:22322133</ref> <ref>PMID:21999818</ref> <ref>PMID:22159456</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN] Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
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Authors: Sandmark, J., Oster, L., Fjellstrom, O., Akkaya, S., Beisel, H.G., Eriksson, P.O., Erixon, K., Gustafsson, D., Jurva, U., Kang, D., Karis, D., Knecht, W., Nerme, V., Nilsson, I., Olsson, T., Redzic, A., Roth, R., Tigerstrom, A.
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==See Also==
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*[[Factor XIa 3D structures|Factor XIa 3D structures]]
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Description: Creating novel F1 inhibitors through fragment based lead generation and structure aided drug design
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Akkaya S]]
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[[Category: Beisel HG]]
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[[Category: Eriksson PO]]
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[[Category: Erixon K]]
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[[Category: Fjellstrom O]]
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[[Category: Gustafsson D]]
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[[Category: Jurva U]]
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[[Category: Kang D]]
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[[Category: Karis D]]
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[[Category: Knecht W]]
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[[Category: Nerme V]]
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[[Category: Nilsson I]]
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[[Category: Olsson T]]
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[[Category: Oster L]]
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[[Category: Redzic A]]
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[[Category: Roth R]]
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[[Category: Sandmark J]]
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[[Category: Tigerstrom A]]

Current revision

Creating novel F1 inhibitors through fragment based lead generation and structure aided drug design

PDB ID 4crf

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