4p0t

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'''Unreleased structure'''
 
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The entry 4p0t is ON HOLD
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==Crystal structure of human centromere protein M==
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<StructureSection load='4p0t' size='340' side='right'caption='[[4p0t]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4p0t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P0T FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.493&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p0t OCA], [https://pdbe.org/4p0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p0t RCSB], [https://www.ebi.ac.uk/pdbsum/4p0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p0t ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CENPM_HUMAN CENPM_HUMAN] Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.<ref>PMID:16716197</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Kinetochores, multi-subunit complexes that assemble at the interface with centromeres, bind spindle microtubules to ensure faithful delivery of chromosomes during cell division. The configuration and function of the kinetochore-centromere interface is poorly understood. We report that a protein at this interface, CENP-M, is structurally and evolutionarily related to small GTPases but is incapable of GTP-binding and conformational switching. We show that CENP-M is crucially required for the assembly and stability of a tetramer also comprising CENP-I, CENP-H, and CENP-K, the HIKM complex, which we extensively characterize through a combination of structural, biochemical, and cell biological approaches. A point mutant affecting the CENP-M/CENP-I interaction hampers kinetochore assembly and chromosome alignment and prevents kinetochore recruitment of the CENP-T/W complex, questioning a role of CENP-T/W as founder of an independent axis of kinetochore assembly. Our studies identify a single pathway having CENP-C as founder, and CENP-H/I/K/M and CENP-T/W as CENP-C-dependent followers.DOI: http://dx.doi.org/10.7554/eLife.02978.001.
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Authors: Basilico, F., Pasqualato, S., Musacchio, A.
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The pseudo GTPase CENP-M drives human kinetochore assembly.,Basilico F, Maffini S, Weir JR, Prumbaum D, Rojas AM, Zimniak T, De Antoni A, Jeganathan S, Voss B, van Gerwen S, Krenn V, Massimiliano L, Valencia A, Vetter IR, Herzog F, Raunser S, Pasqualato S, Musacchio A Elife (Cambridge). 2014 Jul 8;3:e02978. doi: 10.7554/eLife.02978. PMID:25006165<ref>PMID:25006165</ref>
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Description: Crystal structure of human centromere protein M
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4p0t" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Centromere protein 3D structure|Centromere protein 3D structure]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Basilico F]]
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[[Category: Musacchio A]]
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[[Category: Pasqualato S]]

Current revision

Crystal structure of human centromere protein M

PDB ID 4p0t

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