4jgv

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{{STRUCTURE_4jgv| PDB=4jgv | SCENE= }}
 
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===Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with THPN===
 
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{{ABSTRACT_PUBMED_24316735}}
 
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==Function==
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==Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with THPN==
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[[http://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN]] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>
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<StructureSection load='4jgv' size='340' side='right'caption='[[4jgv]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4jgv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JGV FirstGlance]. <br>
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[[4jgv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGV OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.01&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=T94:1-(3,4,5-TRIHYDROXYPHENYL)NONAN-1-ONE'>T94</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jgv OCA], [https://pdbe.org/4jgv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jgv RCSB], [https://www.ebi.ac.uk/pdbsum/4jgv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jgv ProSAT]</span></td></tr>
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<ref group="xtra">PMID:024316735</ref><references group="xtra"/><references/>
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</table>
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[[Category: Chen, H.]]
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== Function ==
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[[Category: Li, A.]]
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[https://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>
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[[Category: Li, F.]]
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== References ==
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[[Category: Lin, T.]]
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<references/>
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[[Category: Tian, X.]]
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__TOC__
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[[Category: Wan, W.]]
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</StructureSection>
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[[Category: Wan, Y.]]
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[[Category: Homo sapiens]]
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[[Category: Wu, Q.]]
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[[Category: Large Structures]]
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[[Category: Xing, Y.]]
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[[Category: Chen H]]
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[[Category: Zhang, Q.]]
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[[Category: Li A]]
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[[Category: Transcription]]
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[[Category: Li F]]
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[[Category: Lin T]]
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[[Category: Tian X]]
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[[Category: Wan W]]
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[[Category: Wan Y]]
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[[Category: Wu Q]]
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[[Category: Xing Y]]
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[[Category: Zhang Q]]

Current revision

Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with THPN

PDB ID 4jgv

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