4ibf

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{{STRUCTURE_4ibf| PDB=4ibf | SCENE= }}
 
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===Ebola virus VP35 bound to small molecule===
 
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{{ABSTRACT_PUBMED_24495995}}
 
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==Function==
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==Ebola virus VP35 bound to small molecule==
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[[http://www.uniprot.org/uniprot/VP35_EBOZM VP35_EBOZM]] Acsts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.<ref>PMID:9971816</ref> <ref>PMID:11027311</ref> <ref>PMID:12829834</ref> <ref>PMID:16495261</ref> <ref>PMID:17065211</ref>
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<StructureSection load='4ibf' size='340' side='right'caption='[[4ibf]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4ibf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebola_virus_-_Mayinga,_Zaire,_1976 Ebola virus - Mayinga, Zaire, 1976]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IBF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IBF FirstGlance]. <br>
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[[4ibf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IBF OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.291&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1D5:(4-{(2R)-2-(4-BROMOTHIOPHEN-2-YL)-3-[(5-CHLOROTHIOPHEN-2-YL)CARBONYL]-4-HYDROXY-5-OXO-2,5-DIHYDRO-1H-PYRROL-1-YL}PHENYL)ACETIC+ACID'>1D5</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ibf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ibf OCA], [https://pdbe.org/4ibf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ibf RCSB], [https://www.ebi.ac.uk/pdbsum/4ibf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ibf ProSAT]</span></td></tr>
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<ref group="xtra">PMID:024495995</ref><references group="xtra"/><references/>
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</table>
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[[Category: Amarasinghe, G K.]]
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== Function ==
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[[Category: Binning, J M.]]
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[https://www.uniprot.org/uniprot/VP35_EBOZM VP35_EBOZM] Acsts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.<ref>PMID:9971816</ref> <ref>PMID:11027311</ref> <ref>PMID:12829834</ref> <ref>PMID:16495261</ref> <ref>PMID:17065211</ref>
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[[Category: Borek, D M.]]
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== References ==
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[[Category: Brown, C S.]]
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<references/>
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[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]]
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__TOC__
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[[Category: Leung, D W.]]
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</StructureSection>
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[[Category: Otwinowski, Z.]]
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[[Category: Ebola virus - Mayinga, Zaire, 1976]]
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[[Category: Peterson, D S.]]
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[[Category: Large Structures]]
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[[Category: Ramanan, P.]]
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[[Category: Amarasinghe GK]]
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[[Category: Stubbs, A J.]]
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[[Category: Binning JM]]
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[[Category: Xu, W.]]
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[[Category: Borek DM]]
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[[Category: Center for structural genomics of infectious disease]]
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[[Category: Brown CS]]
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[[Category: Csgid]]
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[[Category: Leung DW]]
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[[Category: Interferon inhibitor domain]]
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[[Category: Otwinowski Z]]
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[[Category: National institute of allergy and infectious disease]]
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[[Category: Peterson DS]]
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[[Category: Niaid]]
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[[Category: Ramanan P]]
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[[Category: Structural genomic]]
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[[Category: Stubbs AJ]]
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[[Category: Transcription-transcription inhibitor complex]]
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[[Category: Xu W]]

Current revision

Ebola virus VP35 bound to small molecule

PDB ID 4ibf

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