5tss

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[[Image:5tss.gif|left|200px]]<br /><applet load="5tss" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="5tss, resolution 2.9&Aring;" />
 
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'''TOXIC SHOCK SYNDROME TOXIN-1: ORTHORHOMBIC P222(1) CRYSTAL FORM'''<br />
 
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==Overview==
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==TOXIC SHOCK SYNDROME TOXIN-1: ORTHORHOMBIC P222(1) CRYSTAL FORM==
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The structure of toxic shock syndrome toxin-1 (TSST-1), the causative agent in toxic shock syndrome, has been determined in three crystal forms. The three structural models have been refined to R-factors of 0.154, 0.150, and 0.198 at resolutions of 2.05 A, 2.90 A, and 2.75 A, respectively. One crystal form of TSST-1 contains a zinc ion bound between two symmetry-related molecules. Although not required for biological activity, zinc dramatically potentiates the mitogenicity of TSST-1 at very low concentrations. In addition, the structure of the tetramutant TSST-1H [T69I, Y80W, E132K, I140T], which is nonmitogenic and does not amplify endotoxin shock, has been determined and refined in a fourth crystal form (R-factor = 0.173 to 1.9 A resolution).
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<StructureSection load='5tss' size='340' side='right'caption='[[5tss]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[5tss]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TSS FirstGlance]. <br>
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5TSS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TSS OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tss OCA], [https://pdbe.org/5tss PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tss RCSB], [https://www.ebi.ac.uk/pdbsum/5tss PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tss ProSAT]</span></td></tr>
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==Reference==
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</table>
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Refined structures of three crystal forms of toxic shock syndrome toxin-1 and of a tetramutant with reduced activity., Prasad GS, Radhakrishnan R, Mitchell DT, Earhart CA, Dinges MM, Cook WJ, Schlievert PM, Ohlendorf DH, Protein Sci. 1997 Jun;6(6):1220-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9194182 9194182]
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== Function ==
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[[Category: Single protein]]
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[https://www.uniprot.org/uniprot/TSST_STAAU TSST_STAAU] Responsible for the symptoms of toxic shock syndrome.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ts/5tss_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=5tss ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Cook, W J.]]
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[[Category: Cook WJ]]
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[[Category: Dinges, M M.]]
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[[Category: Dinges MM]]
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[[Category: Earhart, C A.]]
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[[Category: Earhart CA]]
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[[Category: Mitchell, D T.]]
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[[Category: Mitchell DT]]
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[[Category: Ohlendorf, D H.]]
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[[Category: Ohlendorf DH]]
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[[Category: Prasad, G S.]]
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[[Category: Prasad GS]]
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[[Category: Radhakrishnan, R.]]
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[[Category: Radhakrishnan R]]
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[[Category: Schlivert, P M.]]
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[[Category: Schlivert PM]]
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[[Category: signal]]
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[[Category: superantigen]]
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[[Category: toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:15:53 2008''
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Current revision

TOXIC SHOCK SYNDROME TOXIN-1: ORTHORHOMBIC P222(1) CRYSTAL FORM

PDB ID 5tss

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