3m6s

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{{STRUCTURE_3m6s| PDB=3m6s | SCENE= }}
 
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===Crystal structure of H1N1pdm Hemagglutinin===
 
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{{ABSTRACT_PUBMED_20352039}}
 
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==Function==
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==Crystal structure of H1N1pdm Hemagglutinin==
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[[http://www.uniprot.org/uniprot/C5MV42_9INFA C5MV42_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]
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<StructureSection load='3m6s' size='340' side='right'caption='[[3m6s]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3m6s]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Darwin/2001/2009(H1N1)) Influenza A virus (A/Darwin/2001/2009(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M6S FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m6s OCA], [https://pdbe.org/3m6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m6s RCSB], [https://www.ebi.ac.uk/pdbsum/3m6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m6s ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/C5MV42_9INFA C5MV42_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m6/3m6s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m6s ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The 3D-structure of the major surface viral antigen from the recent H1N1 pandemic influenza virus (A/Darwin/2001/2009) was determined to 2.8 A resolution. The structure was used to analyze changes in the HA that have emerged during the first 11 months of the pandemic and have raised public health concerns. Receptor binding properties of this protein reveals a strict preference for human-type receptors.
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==About this Structure==
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Structure and Receptor binding properties of a pandemic H1N1 virus hemagglutinin.,Yang H, Carney P, Stevens J PLoS Curr Influenza. 2010 Mar 22:RRN1152. PMID:20352039<ref>PMID:20352039</ref>
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[[3m6s]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/darwin/2001/2009(h1n1)) Influenza a virus (a/darwin/2001/2009(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M6S OCA].
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==See Also==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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*[[Hemagglutinin|Hemagglutinin]]
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</div>
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<div class="pdbe-citations 3m6s" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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<ref group="xtra">PMID:020352039</ref><references group="xtra"/><references/>
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
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[[Category: Carney, P J.]]
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== References ==
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[[Category: Stevens, J.]]
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<references/>
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[[Category: Yang, H.]]
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__TOC__
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[[Category: Envelope protein]]
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</StructureSection>
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[[Category: Fusion protein]]
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[[Category: Large Structures]]
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[[Category: Hemagglutinin]]
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[[Category: Carney PJ]]
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[[Category: Host cell membrane]]
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[[Category: Stevens J]]
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[[Category: Host membrane]]
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[[Category: Yang H]]
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[[Category: Influenza virus]]
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[[Category: Membrane]]
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[[Category: Pandemic]]
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[[Category: Transmembrane]]
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[[Category: Viral protein]]
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[[Category: Virion]]
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Current revision

Crystal structure of H1N1pdm Hemagglutinin

PDB ID 3m6s

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