L-rhamnose isomerase

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<StructureSection load='1de6' size='350' side='right' caption='Structure of L-rhamnose isomerase tetramer complex with L-rhamnitol (PDB entry [[1de6]])' scene=''>
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<StructureSection load='1de6' size='350' side='right' caption='Structure of L-rhamnose isomerase tetramer complex with L-rhamnitol (PDB entry [[1de6]])' scene='55/551207/Cv/6' pspeed='8'>
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== Function ==
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'''L-rhamnose isomerase''' (LRI) catalyzes the interconversion of L-rhamnose to L-rhamnulose or D-allose to D-psicose. LRI participates in fructose and mannose metabolism.
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'''L-rhamnose isomerase''' (LRI) catalyzes the interconversion of L-rhamnose to L-rhamnulose or D-allose to D-psicose. LRI participates in fructose and mannose metabolism<ref>PMID:15342115</ref>.
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== Structural highlights ==
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The biological assembly of LRI from ''Escherichia coli'' is <scene name='55/551207/Cv/8'>homotetramer</scene>. The <scene name='55/551207/Cv/9'>active site</scene> of LRI contains <scene name='55/551207/Cv/10'>catalytic Zn+2 and Mn+2 ions</scene><ref>PMID:10891278</ref>. Water molecules shown as red spheres.
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</StructureSection>
==3D structures of L-rhamnose isomerase==
==3D structures of L-rhamnose isomerase==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[1d8w]] – EcLRI + Zn – ''Escherichia coli''<BR />
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*L-rhamnose isomerase
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[[2hcv]], [[3itx]], [[3ity]], [[3iud]], [[3iui]], [[3iuh]] – PsLRI (mutant) + metal ion – ''Pseudomonas stutzeri''<BR />
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[[3p14]] – BhLRI – ''Bacillus halodurans''<BR />
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[[3uu0]] – BhLRI + Mn<BR />
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[[3uva]], [[3uxi]] – BhLRI (mutant) + Mn<BR />
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===LRI complexes with reactants===
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**[[1d8w]] – EcLRI + Zn – ''Escherichia coli''<BR />
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**[[2hcv]], [[3itx]], [[3ity]], [[3iud]], [[3iui]], [[3iuh]] – PsLRI (mutant) + metal ion – ''Pseudomonas stutzeri''<BR />
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**[[3p14]] – BhLRI – ''Bacillus halodurans''<BR />
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**[[3uu0]] – BhLRI + Mn<BR />
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**[[3uva]], [[3uxi]] – BhLRI (mutant) + Mn<BR />
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[[1de5]], [[1de6]] – EcLRI + L-rhamnitol <BR />
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*LRI complexes with reactants
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[[2i56]], [[3itt]], [[3m0h]], [[3m0v]], [[3m0y]] – PsLRI (mutant) + L-rhamnose<BR />
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[[3itl]] – PsLRI (mutant) + L-rhamnulose<BR />
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[[2i57]], [[3m0m]] – PsLRI (mutant) + D-allose<BR />
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[[3ito]], [[3itv]], [[3m0l]], [[3m0x]] – PsLRI (mutant) + D-psicose<BR />
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[[4gji]] – PsLRI (mutant) + L-rhamnopyranose<BR />
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[[4gjj]] – PsLRI (mutant) + D-alloopyranose<BR />
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**[[1de5]], [[1de6]] – EcLRI + L-rhamnitol <BR />
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**[[2i56]], [[3itt]], [[3m0h]], [[3m0v]], [[3m0y]] – PsLRI (mutant) + L-rhamnose<BR />
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**[[3itl]] – PsLRI (mutant) + L-rhamnulose<BR />
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**[[2i57]], [[3m0m]] – PsLRI (mutant) + D-allose<BR />
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**[[3ito]], [[3itv]], [[3m0l]], [[3m0x]] – PsLRI (mutant) + D-psicose<BR />
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**[[4gji]] – PsLRI (mutant) + L-rhamnopyranose<BR />
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**[[4gjj]] – PsLRI (mutant) + D-alloopyranose<BR />
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of L-rhamnose isomerase tetramer complex with L-rhamnitol (PDB entry 1de6)

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3D structures of L-rhamnose isomerase

Updated on 03-July-2019

References

  1. ↑ Leang K, Takada G, Fukai Y, Morimoto K, Granstrom TB, Izumori K. Novel reactions of L-rhamnose isomerase from Pseudomonas stutzeri and its relation with D-xylose isomerase via substrate specificity. Biochim Biophys Acta. 2004 Sep 6;1674(1):68-77. PMID:15342115 doi:http://dx.doi.org/10.1016/j.bbagen.2004.06.003
  2. ↑ Korndorfer IP, Fessner WD, Matthews BW. The structure of rhamnose isomerase from Escherichia coli and its relation with xylose isomerase illustrates a change between inter and intra-subunit complementation during evolution. J Mol Biol. 2000 Jul 21;300(4):917-33. PMID:10891278 doi:http://dx.doi.org/10.1006/jmbi.2000.3896

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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