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4nwl

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{{STRUCTURE_4nwl| PDB=4nwl | SCENE= }}
 
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===Crystal structure of hepatis c virus protease (ns3) complexed with bms-650032 aka n-(tert-butoxycarbonyl)-3-me thyl-l-valyl-(4r)-4-((7-chloro-4-methoxy-1-isoquinolinyl)o xy)-n-((1r,2s)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylc yclopropyl)-l-prolinamide===
 
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{{ABSTRACT_PUBMED_24555570}}
 
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==About this Structure==
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==Crystal structure of hepatis c virus protease (ns3) complexed with bms-650032 aka n-(tert-butoxycarbonyl)-3-me thyl-l-valyl-(4r)-4-((7-chloro-4-methoxy-1-isoquinolinyl)o xy)-n-((1r,2s)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylc yclopropyl)-l-prolinamide==
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[[4nwl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NWL OCA].
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<StructureSection load='4nwl' size='340' side='right'caption='[[4nwl]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4nwl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_C_virus_genotype_1a Hepatitis C virus genotype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NWL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2R9:N-(TERT-BUTOXYCARBONYL)-3-METHYL-L-VALYL-(4R)-4-[(7-CHLORO-4-METHOXYISOQUINOLIN-1-YL)OXY]-N-{(1R,2S)-1-[(CYCLOPROPYLSULFONYL)CARBAMOYL]-2-ETHENYLCYCLOPROPYL}-L-PROLINAMIDE'>2R9</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nwl OCA], [https://pdbe.org/4nwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nwl RCSB], [https://www.ebi.ac.uk/pdbsum/4nwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nwl ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A8DG50_9HEPC A8DG50_9HEPC]
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==Reference==
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==See Also==
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<ref group="xtra">PMID:024555570</ref><references group="xtra"/><references/>
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*[[Virus protease 3D structures|Virus protease 3D structures]]
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[[Category: Klei, H E.]]
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__TOC__
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[[Category: Muckelbauer, J K.]]
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</StructureSection>
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Hepatitis C virus genotype 1a]]
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[[Category: Hydrolase/hydrolase inhibitor]]
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[[Category: Large Structures]]
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[[Category: Serine protease]]
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[[Category: Klei HE]]
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[[Category: Muckelbauer JK]]

Current revision

Crystal structure of hepatis c virus protease (ns3) complexed with bms-650032 aka n-(tert-butoxycarbonyl)-3-me thyl-l-valyl-(4r)-4-((7-chloro-4-methoxy-1-isoquinolinyl)o xy)-n-((1r,2s)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylc yclopropyl)-l-prolinamide

PDB ID 4nwl

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