4o4l

{{STRUCTURE_4o4l| PDB=4o4l | SCENE= }}

===Tubulin-Peloruside A-Epothilone A complex===

{{ABSTRACT_PUBMED_24470331}}

==Function==

[[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

==About this Structure==

[[4o4l]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O4L OCA].

 

<ref group="xtra">PMID:024470331</ref><references group="xtra"/><references/>

[[Category: Altmann, K H.]]

[[Category: Bargsten, K.]]

[[Category: Diaz, J F.]]

[[Category: Marsh, M.]]

[[Category: Miller, J H.]]

[[Category: Northcote, P T.]]

[[Category: Prota, A E.]]

[[Category: Steinmetz, M O.]]

[[Category: Alpha-tubulin]]

[[Category: Beta-tubulin]]

[[Category: Cell cycle-inhibitor complex]]

[[Category: Cytoskeleton]]

[[Category: Tubulin fold]]