4bf4

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{{Large structure}}
 
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{{STRUCTURE_4bf4| PDB=4bf4 | SCENE= }}
 
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===PikC D50N mutant in complex with the engineered cycloalkane substrate mimic bearing a termianl N,N-dimethylamino group===
 
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==About this Structure==
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==PikC D50N mutant in complex with the engineered cycloalkane substrate mimic bearing a termianl N,N-dimethylamino group==
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[[4bf4]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BF4 OCA].
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<StructureSection load='4bf4' size='340' side='right'caption='[[4bf4]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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[[Category: Podust, L M.]]
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== Structural highlights ==
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[[Category: Monooxygenase]]
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<table><tr><td colspan='2'>[[4bf4]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_venezuelae Streptomyces venezuelae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BF4 FirstGlance]. <br>
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[[Category: Oxidoreductase]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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[[Category: Pikromycin biosynthesis]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=17Q:1.7.6+5-CYCLODODECYLOXY-N,N-DIMETHYL-PENTAN-1-AMINE'>17Q</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bf4 OCA], [https://pdbe.org/4bf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bf4 RCSB], [https://www.ebi.ac.uk/pdbsum/4bf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bf4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PIKC_STRVZ PIKC_STRVZ] Catalyzes the hydroxylation of narbomycin to give rise to pikromycin, and of 10-deoxymethymycin (YC-17) to give rise to methymycin and neomethymycin during macrolide antibiotic biosynthesis. In addition, produces low amounts of neopicromycin, novapikromycin and novamethymycin. Requires the participation of a ferredoxin and a ferredoxin reductase for the transfer of electrons from NADPH to the monooxygenase.<ref>PMID:16825192</ref> <ref>PMID:19124459</ref> <ref>PMID:19833867</ref> <ref>PMID:24627965</ref> <ref>PMID:9778370</ref> <ref>PMID:9831532</ref>
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==See Also==
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*[[Cytochrome P450 hydroxylase 3D structures|Cytochrome P450 hydroxylase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Streptomyces venezuelae]]
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[[Category: Podust LM]]

Current revision

PikC D50N mutant in complex with the engineered cycloalkane substrate mimic bearing a termianl N,N-dimethylamino group

PDB ID 4bf4

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