4m3l

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{{STRUCTURE_4m3l| PDB=4m3l | SCENE= }}
 
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===Crystal Structure of the coiled coil domain of MuRF1===
 
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==Function==
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==Crystal Structure of the coiled coil domain of MuRF1==
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[[http://www.uniprot.org/uniprot/TRI63_HUMAN TRI63_HUMAN]] E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.<ref>PMID:11927605</ref>
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<StructureSection load='4m3l' size='340' side='right'caption='[[4m3l]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4m3l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M3L FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m3l OCA], [https://pdbe.org/4m3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m3l RCSB], [https://www.ebi.ac.uk/pdbsum/4m3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m3l ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRI63_HUMAN TRI63_HUMAN] E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.<ref>PMID:11927605</ref>
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==About this Structure==
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==See Also==
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[[4m3l]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M3L OCA].
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*[[Mur ligase|Mur ligase]]
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
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==Reference==
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== References ==
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<references group="xtra"/><references/>
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<references/>
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[[Category: Franke, B.]]
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__TOC__
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[[Category: Mayans, O.]]
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</StructureSection>
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[[Category: E3 ubiquitin ligase]]
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[[Category: Homo sapiens]]
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[[Category: Ligase]]
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[[Category: Large Structures]]
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[[Category: Sarcoskeleton]]
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[[Category: Franke B]]
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[[Category: Titin]]
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[[Category: Mayans O]]

Current revision

Crystal Structure of the coiled coil domain of MuRF1

PDB ID 4m3l

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