4nmh

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{{STRUCTURE_4nmh| PDB=4nmh | SCENE= }}
 
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===11-beta-HSD1 in complex with a 3,3-Di-methyl-azetidin-2-one===
 
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==Function==
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==11-beta-HSD1 in complex with a 3,3-Di-methyl-azetidin-2-one==
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[[http://www.uniprot.org/uniprot/DHI1_MOUSE DHI1_MOUSE]] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone.
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<StructureSection load='4nmh' size='340' side='right'caption='[[4nmh]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4nmh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NMH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2KG:(4S)-4-(2-METHOXYPHENYL)-3,3-DIMETHYL-1-[3-(METHYLSULFONYL)PHENYL]AZETIDIN-2-ONE'>2KG</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nmh OCA], [https://pdbe.org/4nmh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nmh RCSB], [https://www.ebi.ac.uk/pdbsum/4nmh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nmh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DHI1_MOUSE DHI1_MOUSE] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone.
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==About this Structure==
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==See Also==
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[[4nmh]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NMH OCA].
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*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
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[[Category: 11-beta-hydroxysteroid dehydrogenase]]
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__TOC__
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[[Category: Augustin, M.]]
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</StructureSection>
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[[Category: Blake, C.]]
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[[Category: Large Structures]]
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[[Category: Ertan, A.]]
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[[Category: Mus musculus]]
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[[Category: Gerhardt, S.]]
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[[Category: Augustin M]]
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[[Category: Kilgour, E K.]]
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[[Category: Blake C]]
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[[Category: Krapp, S.]]
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[[Category: Ertan A]]
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[[Category: McCoull, W.]]
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[[Category: Gerhardt S]]
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[[Category: Moore, J E.]]
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[[Category: Kilgour EK]]
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[[Category: Newcombe, N J.]]
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[[Category: Krapp S]]
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[[Category: Ogg, D J.]]
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[[Category: McCoull W]]
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[[Category: Packer, M J.]]
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[[Category: Moore JE]]
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[[Category: Rees, A.]]
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[[Category: Newcombe NJ]]
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[[Category: Revill, J.]]
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[[Category: Ogg DJ]]
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[[Category: Scott, J S.]]
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[[Category: Packer MJ]]
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[[Category: Selmi, N.]]
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[[Category: Rees A]]
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[[Category: Steinbacher, S.]]
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[[Category: Revill J]]
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[[Category: Whittamore, P R.O.]]
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[[Category: Scott JS]]
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[[Category: Oxidoreductase]]
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[[Category: Selmi N]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Steinbacher S]]
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[[Category: Whittamore PRO]]

Current revision

11-beta-HSD1 in complex with a 3,3-Di-methyl-azetidin-2-one

PDB ID 4nmh

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