4o25
From Proteopedia
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| - | {{STRUCTURE_4o25| PDB=4o25 | SCENE= }} | ||
| - | ===Structure of Wild Type Mus musculus Rheb bound to GTP=== | ||
| - | == | + | ==Structure of Wild Type Mus musculus Rheb bound to GTP== |
| - | [[http://www.uniprot.org/uniprot/RHEB_MOUSE RHEB_MOUSE | + | <StructureSection load='4o25' size='340' side='right'caption='[[4o25]], [[Resolution|resolution]] 2.20Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4o25]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O25 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O25 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o25 OCA], [https://pdbe.org/4o25 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o25 RCSB], [https://www.ebi.ac.uk/pdbsum/4o25 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o25 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RHEB_MOUSE RHEB_MOUSE] Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity (By similarity). | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]] |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | + | [[Category: Ho J]] | |
| - | [[Category: | + | [[Category: Ikura M]] |
| - | [[Category: | + | [[Category: Ishiyama N]] |
| - | [[Category: | + | [[Category: Marshall CB]] |
| - | [[Category: | + | [[Category: Mazhab-Jafari MT]] |
| + | [[Category: Stambolic V]] | ||
Current revision
Structure of Wild Type Mus musculus Rheb bound to GTP
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