4lvq

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{{STRUCTURE_4lvq| PDB=4lvq | SCENE= }}
 
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===Crystal structure of the M. tuberculosis phosphate binding protein PstS3===
 
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{{ABSTRACT_PUBMED_24615888}}
 
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==Function==
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==Crystal structure of the M. tuberculosis phosphate binding protein PstS3==
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[[http://www.uniprot.org/uniprot/PSTS3_MYCTU PSTS3_MYCTU]] Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity).
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<StructureSection load='4lvq' size='340' side='right'caption='[[4lvq]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4lvq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LVQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvq OCA], [https://pdbe.org/4lvq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lvq RCSB], [https://www.ebi.ac.uk/pdbsum/4lvq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lvq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PSTS3_MYCTU PSTS3_MYCTU] Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Mycobacterium tuberculosis evades host immune responses by colonizing macrophages. Intraphagosomal M. tuberculosis is exposed to environmental stresses such as reactive oxygen and nitrogen intermediates as well as acid shock and inorganic phosphate (Pi) depletion. Experimental evidence suggests that expression levels of mycobacterial protein PstS3 (Rv0928) are significantly increased when M. tuberculosis bacilli are exposed to Pi starvation. Hence, PstS3 may be important for survival of Mtb in conditions where there is limited supply of Pi. We report here the structure of PstS3 from M. tuberculosis at 2.3-A resolution. The protein presents a structure typical for ABC phosphate transfer receptors. Comparison with its cognate receptor PstS1 showed a different pattern distribution of surface charges in proximity to the Pi recognition site, suggesting complementary roles of the two proteins in Pi uptake. Proteins 2014. (c) 2014 Wiley Periodicals, Inc.
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==About this Structure==
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Crystal structure of the Mycobacterium tuberculosis phosphate binding protein PstS3.,Ferraris DM, Spallek R, Oehlmann W, Singh M, Rizzi M Proteins. 2014 Mar 11. doi: 10.1002/prot.24548. PMID:24615888<ref>PMID:24615888</ref>
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[[4lvq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVQ OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:024615888</ref><references group="xtra"/><references/>
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</div>
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[[Category: Ferraris, D M.]]
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<div class="pdbe-citations 4lvq" style="background-color:#fffaf0;"></div>
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[[Category: Rizzi, M.]]
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[[Category: Extracellular]]
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==See Also==
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[[Category: Phosphate binding protein]]
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*[[Phosphate-binding protein|Phosphate-binding protein]]
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[[Category: Transport protein]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Ferraris DM]]
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[[Category: Rizzi M]]

Current revision

Crystal structure of the M. tuberculosis phosphate binding protein PstS3

PDB ID 4lvq

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