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4npl

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{{STRUCTURE_4npl| PDB=4npl | SCENE= }}
 
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===Crystal structure of Zebrafish ALKBH5 in complex with alpha-ketoglutarate===
 
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{{ABSTRACT_PUBMED_24561204}}
 
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==Function==
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==Crystal structure of Zebrafish ALKBH5 in complex with alpha-ketoglutarate==
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[[http://www.uniprot.org/uniprot/ALKB5_DANRE ALKB5_DANRE]] Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).
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<StructureSection load='4npl' size='340' side='right'caption='[[4npl]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4npl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NPL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.651&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4npl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4npl OCA], [https://pdbe.org/4npl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4npl RCSB], [https://www.ebi.ac.uk/pdbsum/4npl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4npl ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALKB5_DANRE ALKB5_DANRE] Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).
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==About this Structure==
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==See Also==
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[[4npl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPL OCA].
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*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:024561204</ref><references group="xtra"/><references/>
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[[Category: Danio rerio]]
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[[Category: Chen, W.]]
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[[Category: Large Structures]]
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[[Category: He, C.]]
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[[Category: Chen W]]
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[[Category: Zhang, L.]]
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[[Category: He C]]
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[[Category: Oxidoreductase]]
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[[Category: Zhang L]]

Current revision

Crystal structure of Zebrafish ALKBH5 in complex with alpha-ketoglutarate

PDB ID 4npl

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