2mn3
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2mn3 is ON HOLD Authors: Torres, A.M., Bansal, P.S., Koh, J.MS., Pages, G., Wu, M.J., Kuchel, P.W. Description: Structure of Platypus 'Intermediate...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of Platypus 'Intermediate' Defensin-like Peptide (Int-DLP)== | |
| + | <StructureSection load='2mn3' size='340' side='right'caption='[[2mn3]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2mn3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ornithorhynchus_anatinus Ornithorhynchus anatinus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MN3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MN3 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mn3 OCA], [https://pdbe.org/2mn3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mn3 RCSB], [https://www.ebi.ac.uk/pdbsum/2mn3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mn3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DEFBL_ORNAN DEFBL_ORNAN] Has antimicrobial activity. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The three-dimensional structure of a chemically synthesized peptide that we have called 'intermediate' defensin-like peptide (Int-DLP), from the platypus genome, was determined by nuclear magnetic resonance (NMR) spectroscopy; and its antimicrobial activity was investigated. The overall structural fold of Int-DLP was similar to that of the DLPs and beta-defensins, however the presence of a third antiparallel beta-strand makes its structure more similar to the beta-defensins than the DLPs. Int-DLP displayed potent antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa. The four arginine residues at the N-terminus of Int-DLP did not affect the overall fold, but were important for its antimicrobial potency. | ||
| - | + | Structure and antimicrobial activity of platypus 'intermediate' defensin-like peptide.,Torres AM, Bansal P, Koh JM, Pages G, Wu MJ, Kuchel PW FEBS Lett. 2014 May 2;588(9):1821-6. doi: 10.1016/j.febslet.2014.03.044. Epub, 2014 Mar 30. PMID:24694388<ref>PMID:24694388</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 2mn3" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ornithorhynchus anatinus]] | ||
| + | [[Category: Bansal PS]] | ||
| + | [[Category: Koh JMS]] | ||
| + | [[Category: Kuchel PW]] | ||
| + | [[Category: Pages G]] | ||
| + | [[Category: Torres AM]] | ||
| + | [[Category: Wu MJ]] | ||
Current revision
Structure of Platypus 'Intermediate' Defensin-like Peptide (Int-DLP)
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