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3j6j

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'''Unreleased structure'''
 
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The entry 3j6j is ON HOLD until sometime in the future
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==3.6 Angstrom resolution MAVS filament generated from helical reconstruction==
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<SX load='3j6j' size='340' side='right' viewer='molstar' caption='[[3j6j]], [[Resolution|resolution]] 3.64&Aring;' scene=''>
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Authors: Wu B, Peisley A, Li Z, Egelman E, Walz T, Penczek P, Hur S
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3j6j]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J6J FirstGlance]. <br>
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Description: 3.6A filament data generated from helical reconstruction
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.64&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6j OCA], [https://pdbe.org/3j6j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j6j RCSB], [https://www.ebi.ac.uk/pdbsum/3j6j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j6j ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MAVS_HUMAN MAVS_HUMAN] Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.<ref>PMID:16125763</ref> <ref>PMID:16153868</ref> <ref>PMID:16177806</ref> <ref>PMID:16127453</ref> <ref>PMID:19631370</ref> <ref>PMID:20451243</ref>
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== References ==
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<references/>
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__TOC__
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</SX>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Egelman E]]
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[[Category: Hur S]]
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[[Category: Li Z]]
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[[Category: Peisley A]]
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[[Category: Penczek P]]
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[[Category: Walz T]]
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[[Category: Wu B]]

Current revision

3.6 Angstrom resolution MAVS filament generated from helical reconstruction

3j6j, resolution 3.64Å

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