4cv8
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4cv8 is ON HOLD until Paper Publication Authors: Fearon, D., Bavetsias, V., Bayliss, R., Schmitt, J., Westwood, I.M., vanMontfort, R.L.M., Jones, K....) |
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| - | '''Unreleased structure''' | ||
| - | + | ==MPS1 kinase with 3-aminopyridin-2-one inhibitors== | |
| + | <StructureSection load='4cv8' size='340' side='right'caption='[[4cv8]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4cv8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CV8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3D7:3-AMINO-5-(1-METHYL-1H-PYRAZOL-4-YL)PYRIDIN-2(1H)-ONE'>3D7</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cv8 OCA], [https://pdbe.org/4cv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cv8 RCSB], [https://www.ebi.ac.uk/pdbsum/4cv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cv8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bavetsias V]] | ||
| + | [[Category: Bayliss R]] | ||
| + | [[Category: Fearon D]] | ||
| + | [[Category: Jones K]] | ||
| + | [[Category: Schmitt J]] | ||
| + | [[Category: Westwood IM]] | ||
| + | [[Category: VanMontfort RLM]] | ||
Current revision
MPS1 kinase with 3-aminopyridin-2-one inhibitors
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