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4pyq
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Humanized rat apo-COMT in complex with a ureido-benzamidine== | |
| + | <StructureSection load='4pyq' size='340' side='right'caption='[[4pyq]], [[Resolution|resolution]] 1.39Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4pyq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PYQ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.39Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2X1:4-({[3-(AMINOMETHYL)PHENYL]CARBAMOYL}AMINO)BENZENECARBOXIMIDAMIDE'>2X1</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pyq OCA], [https://pdbe.org/4pyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pyq RCSB], [https://www.ebi.ac.uk/pdbsum/4pyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pyq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/COMT_RAT COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. | ||
| - | + | ==See Also== | |
| - | + | *[[Catechol O-methyltransferase 3D structures|Catechol O-methyltransferase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Benz J]] | ||
| + | [[Category: Ehler A]] | ||
| + | [[Category: Rudolph MG]] | ||
| + | [[Category: Schlatter D]] | ||
Current revision
Humanized rat apo-COMT in complex with a ureido-benzamidine
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