4poo

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{{STRUCTURE_4poo| PDB=4poo | SCENE= }}
 
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===The crystal structure of Bacillus subtilis YtqB in complex with SAM===
 
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{{ABSTRACT_PUBMED_24637210}}
 
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==About this Structure==
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==The crystal structure of Bacillus subtilis YtqB in complex with SAM==
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[[4poo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4POO OCA].
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<StructureSection load='4poo' size='340' side='right'caption='[[4poo]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4poo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._spizizenii_str._W23 Bacillus subtilis subsp. spizizenii str. W23]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4POO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4POO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4poo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4poo OCA], [https://pdbe.org/4poo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4poo RCSB], [https://www.ebi.ac.uk/pdbsum/4poo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4poo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/E0TY72_BACSH E0TY72_BACSH]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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S-adenosyl-l-methionine (SAM)-dependent methyltransferases (MTases) methylate diverse biological molecules using a SAM cofactor. The ytqB gene of Bacillus subtilis encodes a putative MTase and its biological function has never been characterized. To reveal the structural features and the cofactor binding mode of YtqB, we have determined the crystal structures of YtqB alone and in complex with its cofactor, SAM, at 1.9A and 2.2A resolutions, respectively. YtqB folds into a beta-sheet sandwiched by two alpha-helical layers, and assembles into a dimeric form. Each YtqB monomer contains one SAM binding site, which shapes SAM into a slightly curved conformation and exposes the reactive methyl group of SAM potentially to a substrate. Our comparative structural analysis of YtqB and its homologues indicates that YtqB is a SAM-dependent class I MTase, and provides insights into the substrate binding site of YtqB.
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==Reference==
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Structural analysis of a putative SAM-dependent methyltransferase, YtqB, from Bacillus subtilis.,Park SC, Song WS, Yoon SI Biochem Biophys Res Commun. 2014 Mar 14. pii: S0006-291X(14)00460-4. doi:, 10.1016/j.bbrc.2014.03.026. PMID:24637210<ref>PMID:24637210</ref>
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<ref group="xtra">PMID:024637210</ref><references group="xtra"/><references/>
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[[Category: Park, S C.]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Song, W S.]]
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</div>
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[[Category: Yoon, S I.]]
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<div class="pdbe-citations 4poo" style="background-color:#fffaf0;"></div>
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[[Category: A putative methyltransferase]]
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== References ==
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[[Category: Rossmann-like fold]]
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<references/>
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[[Category: S-adenosyl-l-methionine]]
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__TOC__
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[[Category: Transferase]]
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</StructureSection>
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[[Category: Bacillus subtilis subsp. spizizenii str. W23]]
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[[Category: Large Structures]]
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[[Category: Park SC]]
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[[Category: Song WS]]
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[[Category: Yoon SI]]

Current revision

The crystal structure of Bacillus subtilis YtqB in complex with SAM

PDB ID 4poo

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