4nud

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{{STRUCTURE_4nud| PDB=4nud | SCENE= }}
 
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===Crystal structure of the first bromodomain of human BRD4 in complex with MS436 inhibitor===
 
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{{ABSTRACT_PUBMED_24144283}}
 
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==Disease==
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==Crystal structure of the first bromodomain of human BRD4 in complex with MS436 inhibitor==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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<StructureSection load='4nud' size='340' side='right'caption='[[4nud]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4nud]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NUD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NUD:4-[(E)-(2-AMINO-4-HYDROXY-5-METHYLPHENYL)DIAZENYL]-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE'>NUD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nud OCA], [https://pdbe.org/4nud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nud RCSB], [https://www.ebi.ac.uk/pdbsum/4nud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nud ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[4nud]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NUD OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Homo sapiens]]
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<ref group="xtra">PMID:024144283</ref><references group="xtra"/><references/>
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[[Category: Large Structures]]
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[[Category: Joshua, J.]]
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[[Category: Joshua J]]
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[[Category: Plotnikov, A N.]]
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[[Category: Plotnikov AN]]
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[[Category: Zhou, M M.]]
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[[Category: Zhou M-M]]
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[[Category: Transcription]]
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[[Category: Transcription factor]]
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[[Category: Transcription-transcription inhibitor complex]]
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Current revision

Crystal structure of the first bromodomain of human BRD4 in complex with MS436 inhibitor

PDB ID 4nud

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