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| - | {{STRUCTURE_4otw| PDB=4otw | SCENE= }}
| + | #REDIRECT [[6op9]] This PDB entry is obsolete and replaced by 6op9 |
| - | ===HER3 pseudokinase domain bound to bosutinib===
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| - | {{ABSTRACT_PUBMED_24656791}}
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| - | ==Disease==
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| - | [[http://www.uniprot.org/uniprot/ERBB3_HUMAN ERBB3_HUMAN]] Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:[http://omim.org/entry/607598 607598]]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.<ref>PMID:17701904</ref> | + | |
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| - | ==Function==
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| - | [[http://www.uniprot.org/uniprot/ERBB3_HUMAN ERBB3_HUMAN]] Binds and is activated by neuregulins and NTAK.<ref>PMID:15358134</ref>
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| - | ==About this Structure==
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| - | [[4otw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OTW OCA].
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| - | ==Reference==
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| - | <ref group="xtra">PMID:024656791</ref><references group="xtra"/><references/>
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| - | [[Category: Receptor protein-tyrosine kinase]]
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| - | [[Category: Jura, N.]]
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| - | [[Category: Littlefield, P.]]
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| - | [[Category: Bosutinib]]
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| - | [[Category: Membrane]]
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| - | [[Category: Pseudokinase]]
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| - | [[Category: Receptor tyrosine kinase]]
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| - | [[Category: Transferase-transferase inhibitor complex]]
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Current revision
- REDIRECT 6op9 This PDB entry is obsolete and replaced by 6op9
