2ed0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="2ed0" size="350" color="white" frame="true" align="right" spinBox="true" caption="2ed0" /> '''Solution structure of the SH3 domain of Abl ...)
Current revision (18:49, 29 May 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2ed0.jpg|left|200px]]<br /><applet load="2ed0" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2ed0" />
 
-
'''Solution structure of the SH3 domain of Abl interactor 2 (Abelson interactor 2)'''<br />
 
-
==About this Structure==
+
==Solution structure of the SH3 domain of Abl interactor 2 (Abelson interactor 2)==
-
2ED0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ED0 OCA].
+
<StructureSection load='2ed0' size='340' side='right'caption='[[2ed0]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2ed0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ED0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ED0 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ed0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ed0 OCA], [https://pdbe.org/2ed0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ed0 RCSB], [https://www.ebi.ac.uk/pdbsum/2ed0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ed0 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ed0 TOPSAN]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ABI2_HUMAN ABI2_HUMAN] May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.<ref>PMID:7590236</ref> <ref>PMID:8649853</ref> <ref>PMID:10498863</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/2ed0_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ed0 ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Abe, H.]]
+
[[Category: Abe H]]
-
[[Category: Kigawa, T.]]
+
[[Category: Kigawa T]]
-
[[Category: Miyamoto, K.]]
+
[[Category: Miyamoto K]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
[[Category: Saito K]]
-
[[Category: Saito, K.]]
+
[[Category: Tochio N]]
-
[[Category: Tochio, N.]]
+
[[Category: Yokoyama S]]
-
[[Category: Yokoyama, S.]]
+
-
[[Category: coiled coil]]
+
-
[[Category: cytoskeleton]]
+
-
[[Category: national project on protein structural and functional analyses]]
+
-
[[Category: nppsfa]]
+
-
[[Category: nuclear protein]]
+
-
[[Category: phosphorylation]]
+
-
[[Category: riken structural genomics/proteomics initiative]]
+
-
[[Category: rsgi]]
+
-
[[Category: sh3 domain]]
+
-
[[Category: signaling protein]]
+
-
[[Category: structural genomics]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 27 07:57:58 2008''
+

Current revision

Solution structure of the SH3 domain of Abl interactor 2 (Abelson interactor 2)

PDB ID 2ed0

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ed0"
Personal tools