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3oqo

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{{STRUCTURE_3oqo| PDB=3oqo | SCENE= }}
 
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===Ccpa-hpr-ser46p-syn cre===
 
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{{ABSTRACT_PUBMED_21106498}}
 
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==Function==
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==Ccpa-hpr-ser46p-syn cre==
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[[http://www.uniprot.org/uniprot/CCPA_BACSU CCPA_BACSU]] Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions. Interacts with either P-Ser-HPr or P-Ser-Crh, leading to the formation of a complex that binds to DNA at the catabolite-response elements (cre). Binding to DNA allows activation or repression of many different genes and operons.<ref>PMID:1904524</ref> <ref>PMID:7665492</ref> <ref>PMID:10559165</ref> <ref>PMID:11557150</ref> <ref>PMID:21106498</ref> [[http://www.uniprot.org/uniprot/PTHP_BACSU PTHP_BACSU]] General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III).<ref>PMID:8195089</ref> <ref>PMID:8596444</ref> P-Ser-HPr interacts with the catabolite control protein A (CcpA), forming a complex that binds to DNA at the catabolite response elements cre, operator sites preceding a large number of catabolite-regulated genes. Thus, P-Ser-HPr is a corepressor in carbon catabolite repression (CCR), a mechanism that allows bacteria to coordinate and optimize the utilization of available carbon sources. P-Ser-HPr also plays a role in inducer exclusion, in which it probably interacts with several non-PTS permeases and inhibits their transport activity.<ref>PMID:8195089</ref> <ref>PMID:8596444</ref>
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<StructureSection load='3oqo' size='340' side='right'caption='[[3oqo]], [[Resolution|resolution]] 2.97&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3oqo]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OQO FirstGlance]. <br>
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[[3oqo]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OQO OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.97&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oqo OCA], [https://pdbe.org/3oqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oqo RCSB], [https://www.ebi.ac.uk/pdbsum/3oqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oqo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CCPA_BACSU CCPA_BACSU] Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions. Interacts with either P-Ser-HPr or P-Ser-Crh, leading to the formation of a complex that binds to DNA at the catabolite-response elements (cre). Binding to DNA allows activation or repression of many different genes and operons.<ref>PMID:1904524</ref> <ref>PMID:7665492</ref> <ref>PMID:10559165</ref> <ref>PMID:11557150</ref> <ref>PMID:21106498</ref>
==See Also==
==See Also==
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*[[Catabolite control protein|Catabolite control protein]]
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*[[Catabolite control protein 3D structures|Catabolite control protein 3D structures]]
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*[[Phosphocarrier protein HPr|Phosphocarrier protein HPr]]
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*[[Phosphocarrier protein HPr 3D structures|Phosphocarrier protein HPr 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021106498</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Bacillus globigii migula 1900]]
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</StructureSection>
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[[Category: Bartholomae, M.]]
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[[Category: Bacillus subtilis]]
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[[Category: Brennan, R G.]]
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[[Category: Large Structures]]
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[[Category: Hillen, W.]]
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[[Category: Bartholomae M]]
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[[Category: Sprehe, M.]]
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[[Category: Brennan RG]]
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[[Category: Schumacher, M A.]]
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[[Category: Hillen W]]
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[[Category: Cre dna]]
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[[Category: Sprehe M]]
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[[Category: Hpr-ser46p]]
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[[Category: Schumacher MA]]
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[[Category: Nucleoid]]
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[[Category: Pbp fold for ccpa]]
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[[Category: Transcription]]
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[[Category: Transcription-transferase-dna complex]]
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Current revision

Ccpa-hpr-ser46p-syn cre

PDB ID 3oqo

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