4om3

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{{STRUCTURE_4om3| PDB=4om3 | SCENE= }}
 
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===Crystal structure of human TLE1 Q-domain residues 20-156===
 
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{{ABSTRACT_PUBMED_24596249}}
 
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==Function==
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==Crystal structure of human TLE1 Q-domain residues 20-156==
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[[http://www.uniprot.org/uniprot/TLE1_HUMAN TLE1_HUMAN]] Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.<ref>PMID:10660609</ref>
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<StructureSection load='4om3' size='340' side='right'caption='[[4om3]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4om3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OM3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OM3 FirstGlance]. <br>
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[[4om3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OM3 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.855&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4om3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4om3 OCA], [https://pdbe.org/4om3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4om3 RCSB], [https://www.ebi.ac.uk/pdbsum/4om3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4om3 ProSAT]</span></td></tr>
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<ref group="xtra">PMID:024596249</ref><references group="xtra"/><references/>
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</table>
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[[Category: Chodaparambil, J V.]]
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== Function ==
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[[Category: Weis, W I.]]
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[https://www.uniprot.org/uniprot/TLE1_HUMAN TLE1_HUMAN] Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.<ref>PMID:10660609</ref>
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[[Category: Dna binding]]
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== References ==
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[[Category: Helix-turn-helix]]
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<references/>
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[[Category: Tcf/lef]]
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__TOC__
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[[Category: Tetramer]]
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</StructureSection>
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[[Category: Transcription]]
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[[Category: Homo sapiens]]
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[[Category: Wnt repressor]]
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[[Category: Large Structures]]
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[[Category: Chodaparambil JV]]
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[[Category: Weis WI]]

Current revision

Crystal structure of human TLE1 Q-domain residues 20-156

PDB ID 4om3

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