4nft

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{{STRUCTURE_4nft| PDB=4nft | SCENE= }}
 
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===Crystal structure of human lnkH2B-h2A.Z-Anp32e===
 
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{{ABSTRACT_PUBMED_24613878}}
 
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==Function==
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==Crystal structure of human lnkH2B-h2A.Z-Anp32e==
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[[http://www.uniprot.org/uniprot/H2B2E_HUMAN H2B2E_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> [[http://www.uniprot.org/uniprot/AN32E_HUMAN AN32E_HUMAN]] Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis process by modulating PP2A activity (By similarity).
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<StructureSection load='4nft' size='340' side='right'caption='[[4nft]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4nft]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NFT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.61&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nft OCA], [https://pdbe.org/4nft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nft RCSB], [https://www.ebi.ac.uk/pdbsum/4nft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nft ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/H2AZ_HUMAN H2AZ_HUMAN] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.<ref>PMID:15878876</ref> [https://www.uniprot.org/uniprot/H2B2E_HUMAN H2B2E_HUMAN] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>
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==About this Structure==
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==See Also==
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[[4nft]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NFT OCA].
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*[[Histone 3D structures|Histone 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:024613878</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Chen, S.]]
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</StructureSection>
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[[Category: Dai, L.]]
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[[Category: Homo sapiens]]
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[[Category: Ding, X.]]
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[[Category: Large Structures]]
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[[Category: Dong, Q.]]
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[[Category: Chen S]]
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[[Category: Liang, X.]]
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[[Category: Dai L]]
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[[Category: Mao, Z.]]
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[[Category: Ding X]]
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[[Category: Pan, L.]]
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[[Category: Dong Q]]
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[[Category: Shan, S.]]
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[[Category: Liang X]]
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[[Category: Sun, J.]]
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[[Category: Mao Z]]
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[[Category: Wang, W.]]
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[[Category: Pan L]]
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[[Category: Zhang, Z.]]
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[[Category: Shan S]]
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[[Category: Zhou, Z.]]
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[[Category: Sun J]]
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[[Category: Zhu, B.]]
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[[Category: Wang W]]
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[[Category: Chaperone]]
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[[Category: Zhang Z]]
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[[Category: Histone binding protein]]
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[[Category: Zhou Z]]
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[[Category: Zhu B]]

Current revision

Crystal structure of human lnkH2B-h2A.Z-Anp32e

PDB ID 4nft

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