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2zc8
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="2zc8" size="350" color="white" frame="true" align="right" spinBox="true" caption="2zc8, resolution 1.95Å" /> '''Crystal structure of...) |
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| - | [[Image:2zc8.jpg|left|200px]]<br /><applet load="2zc8" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2zc8, resolution 1.95Å" /> | ||
| - | '''Crystal structure of N-Acylamino Acid Racemase from Thermus thermophilus HB8'''<br /> | ||
| - | == | + | ==Crystal structure of N-Acylamino Acid Racemase from Thermus thermophilus HB8== |
| - | + | <StructureSection load='2zc8' size='340' side='right'caption='[[2zc8]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[2zc8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZC8 FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zc8 OCA], [https://pdbe.org/2zc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zc8 RCSB], [https://www.ebi.ac.uk/pdbsum/2zc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zc8 ProSAT]</span></td></tr> |
| - | [ | + | </table> |
| - | [ | + | == Function == |
| - | [[ | + | [https://www.uniprot.org/uniprot/NSAR_THET8 NSAR_THET8] Acts as a N-succinylamino acid racemase (NSAR) that catalyzes the racemization of N-succinyl-L-phenylglycine (PubMed:24872444). Also converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB) (PubMed:24872444). Catalyzes both N-succinylamino acid racemization and OSB synthesis at equivalent rates (PubMed:24872444). However, NSAR activity is probably the protein's biological function, because menaquinone biosynthesis genes are missing in this species (Probable).<ref>PMID:24872444</ref> <ref>PMID:16740275</ref> |
| - | [ | + | == Evolutionary Conservation == |
| - | [[Category: | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [[Category: | + | Check<jmol> |
| - | [[Category: | + | <jmolCheckbox> |
| - | [[Category: | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zc/2zc8_consurf.spt"</scriptWhenChecked> |
| - | [[Category: | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | [[Category: | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | + | </jmolCheckbox> | |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zc8 ConSurf]. | |
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Thermus thermophilus HB8]] | ||
| + | [[Category: Hayashida M]] | ||
| + | [[Category: Hisano T]] | ||
| + | [[Category: Kim SH]] | ||
| + | [[Category: Miki K]] | ||
| + | [[Category: Takeda K]] | ||
Current revision
Crystal structure of N-Acylamino Acid Racemase from Thermus thermophilus HB8
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