4k0n

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{{STRUCTURE_4k0n| PDB=4k0n | SCENE= }}
 
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===Crystal structure of human CLIC1 C24A mutant===
 
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==Function==
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==Crystal structure of human CLIC1 C24A mutant==
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[[http://www.uniprot.org/uniprot/CLIC1_HUMAN CLIC1_HUMAN]] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.<ref>PMID:9139710</ref> <ref>PMID:10834939</ref> <ref>PMID:11195932</ref> <ref>PMID:11940526</ref> <ref>PMID:11978800</ref> <ref>PMID:11551966</ref> <ref>PMID:14613939</ref>
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<StructureSection load='4k0n' size='340' side='right'caption='[[4k0n]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4k0n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K0N FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k0n OCA], [https://pdbe.org/4k0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k0n RCSB], [https://www.ebi.ac.uk/pdbsum/4k0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k0n ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CLIC1_HUMAN CLIC1_HUMAN] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.<ref>PMID:9139710</ref> <ref>PMID:10834939</ref> <ref>PMID:11195932</ref> <ref>PMID:11940526</ref> <ref>PMID:11978800</ref> <ref>PMID:11551966</ref> <ref>PMID:14613939</ref>
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==About this Structure==
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==See Also==
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[[4k0n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K0N OCA].
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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[[Category: Curmi, P M.G.]]
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</StructureSection>
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[[Category: Duff, A P.]]
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[[Category: Homo sapiens]]
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[[Category: Harrop, S J.]]
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[[Category: Large Structures]]
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[[Category: Phang, J M.]]
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[[Category: Curmi PMG]]
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[[Category: Wilk, K E.]]
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[[Category: Duff AP]]
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[[Category: Chloride ion channel]]
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[[Category: Harrop SJ]]
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[[Category: Clic]]
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[[Category: Phang JM]]
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[[Category: Glutathione-s-transferase fold]]
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[[Category: Wilk KE]]
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[[Category: Transport protein]]
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Current revision

Crystal structure of human CLIC1 C24A mutant

PDB ID 4k0n

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