4lxr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:41, 17 October 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_4lxr| PDB=4lxr | SCENE= }}
 
-
===Structure of the Toll - Spatzle complex, a molecular hub in Drosophila development and innate immunity===
 
-
==Function==
+
==Structure of the Toll - Spatzle complex, a molecular hub in Drosophila development and innate immunity==
-
[[http://www.uniprot.org/uniprot/SPZ_DROME SPZ_DROME]] Component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo. Three proteases; ndl, gd and snk process easter to create active easter. Active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the Tl receptor in the ventral region of the embryo. Spz C-106 in the hemolymph controls expression of the antifungal peptide Drosomycin (Drs) by acting as a ligand of Tl and inducing an intracellular signaling pathway.<ref>PMID:8124709</ref> <ref>PMID:11212919</ref> <ref>PMID:8808632</ref> <ref>PMID:12872120</ref>
+
<StructureSection load='4lxr' size='340' side='right'caption='[[4lxr]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4lxr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LXR FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lxr OCA], [https://pdbe.org/4lxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lxr RCSB], [https://www.ebi.ac.uk/pdbsum/4lxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lxr ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TOLL_DROME TOLL_DROME]
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Drosophila Toll receptors are involved in embryonic development and the immune response of adult flies. In both processes, the only known Toll receptor ligand is the human nerve growth factor-like cystine knot protein Spatzle. Here we present the crystal structure of a 1:1 (nonsignaling) complex of the full-length Toll receptor ectodomain (ECD) with the Spatzle cystine knot domain dimer. The ECD is divided into two leucine-rich repeat (LRR) domains, each of which is capped by cysteine-rich domains. Spatzle binds to the concave surface of the membrane-distal LRR domain, in contrast to the flanking ligand interactions observed for mammalian Toll-like receptors, with asymmetric contributions from each Spatzle protomer. The structure allows rationalization of existing genetic and biochemical data and provides a framework for targeting the immune systems of insects of economic importance, as well as a variety of invertebrate disease vectors.
-
==About this Structure==
+
Structure of the Toll-Spatzle complex, a molecular hub in Drosophila development and innate immunity.,Parthier C, Stelter M, Ursel C, Fandrich U, Lilie H, Breithaupt C, Stubbs MT Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6281-6. doi:, 10.1073/pnas.1320678111. Epub 2014 Apr 14. PMID:24733933<ref>PMID:24733933</ref>
-
[[4lxr]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LXR OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<references group="xtra"/><references/>
+
</div>
-
[[Category: Breithaupt, C.]]
+
<div class="pdbe-citations 4lxr" style="background-color:#fffaf0;"></div>
-
[[Category: Parthier, C.]]
+
== References ==
-
[[Category: Stelter, M.]]
+
<references/>
-
[[Category: Stubbs, M T.]]
+
__TOC__
-
[[Category: Cytokine receptor]]
+
</StructureSection>
-
[[Category: Embryonic development]]
+
[[Category: Drosophila melanogaster]]
-
[[Category: Immune system]]
+
[[Category: Large Structures]]
-
[[Category: Immune system-cytokine complex]]
+
[[Category: Breithaupt C]]
-
[[Category: Innate immunity]]
+
[[Category: Parthier C]]
-
[[Category: Leucine-rich repeat]]
+
[[Category: Stelter M]]
-
[[Category: Receptor-ligand complexes']]
+
[[Category: Stubbs MT]]
-
[[Category: Tlr]]
+

Current revision

Structure of the Toll - Spatzle complex, a molecular hub in Drosophila development and innate immunity

PDB ID 4lxr

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4lxr"
Personal tools