4ol0

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{{STRUCTURE_4ol0| PDB=4ol0 | SCENE= }}
 
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===Crystal structure of transportin-SR2, a karyopherin involved in human disease, in complex with Ran===
 
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==Disease==
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==Crystal structure of transportin-SR2, a karyopherin involved in human disease, in complex with Ran==
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[[http://www.uniprot.org/uniprot/TNPO3_HUMAN TNPO3_HUMAN]] Primary biliary cirrhosis;Autosomal dominant limb-girdle muscular dystrophy type 1F.
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<StructureSection load='4ol0' size='340' side='right'caption='[[4ol0]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ol0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OL0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OL0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ol0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ol0 OCA], [https://pdbe.org/4ol0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ol0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ol0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ol0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> [[http://www.uniprot.org/uniprot/TNPO3_HUMAN TNPO3_HUMAN]] Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains.<ref>PMID:10366588</ref> <ref>PMID:10713112</ref> <ref>PMID:11517331</ref> <ref>PMID:12628928</ref>
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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*[[Importin 3D structures|Importin 3D structures]]
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==About this Structure==
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== References ==
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[[4ol0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OL0 OCA].
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<references/>
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__TOC__
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==Reference==
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</StructureSection>
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Strelkov, S V.]]
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[[Category: Large Structures]]
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[[Category: Tsirkone, V G.]]
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[[Category: Strelkov SV]]
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[[Category: Active transport]]
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[[Category: Tsirkone VG]]
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[[Category: Human karyopherin]]
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[[Category: Nucleus]]
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[[Category: Protein transport]]
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[[Category: Ran gtp-binding protein]]
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Current revision

Crystal structure of transportin-SR2, a karyopherin involved in human disease, in complex with Ran

PDB ID 4ol0

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