1aqw
From Proteopedia
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| - | {{STRUCTURE_1aqw| PDB=1aqw | SCENE= }} | ||
| - | ===GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH GLUTATHIONE=== | ||
| - | {{ABSTRACT_PUBMED_9351803}} | ||
| - | == | + | ==GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH GLUTATHIONE== |
| - | [[http://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN | + | <StructureSection load='1aqw' size='340' side='right'caption='[[1aqw]], [[Resolution|resolution]] 1.80Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1aqw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AQW FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aqw OCA], [https://pdbe.org/1aqw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aqw RCSB], [https://www.ebi.ac.uk/pdbsum/1aqw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aqw ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aq/1aqw_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aqw ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Fahl | + | [[Category: Large Structures]] |
| - | [[Category: Huber | + | [[Category: Fahl WE]] |
| - | [[Category: Manoharan | + | [[Category: Huber R]] |
| - | [[Category: Prade | + | [[Category: Manoharan TH]] |
| - | [[Category: Reuter | + | [[Category: Prade L]] |
| - | + | [[Category: Reuter W]] | |
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| - | + | ||
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Current revision
GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH GLUTATHIONE
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Categories: Homo sapiens | Large Structures | Fahl WE | Huber R | Manoharan TH | Prade L | Reuter W
