1d9x
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| - | {{STRUCTURE_1d9x| PDB=1d9x | SCENE= }} | ||
| - | ===CRYSTAL STRUCTURE OF THE DNA REPAIR PROTEIN UVRB=== | ||
| - | {{ABSTRACT_PUBMED_10601012}} | ||
| - | == | + | ==CRYSTAL STRUCTURE OF THE DNA REPAIR PROTEIN UVRB== |
| - | [[http://www.uniprot.org/uniprot/UVRB_BACCA UVRB_BACCA | + | <StructureSection load='1d9x' size='340' side='right'caption='[[1d9x]], [[Resolution|resolution]] 2.60Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1d9x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_caldotenax Bacillus caldotenax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D9X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D9X FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d9x OCA], [https://pdbe.org/1d9x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d9x RCSB], [https://www.ebi.ac.uk/pdbsum/1d9x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d9x ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/UVRB_BACCA UVRB_BACCA] The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity).[HAMAP-Rule:MF_00204] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d9/1d9x_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d9x ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[UvrABC|UvrABC]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| - | [[Category: | + | [[Category: Chen PJ]] |
| - | [[Category: Chen | + | [[Category: Kisker C]] |
| - | + | [[Category: Skorvaga M]] | |
| - | [[Category: Kisker | + | [[Category: Theis K]] |
| - | [[Category: Skorvaga | + | [[Category: Van Houten B]] |
| - | [[Category: Theis | + | |
| - | [[Category: | + | |
| - | + | ||
Current revision
CRYSTAL STRUCTURE OF THE DNA REPAIR PROTEIN UVRB
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