1bfe
From Proteopedia
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| - | {{STRUCTURE_1bfe| PDB=1bfe | SCENE= }} | ||
| - | ===THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95=== | ||
| - | {{ABSTRACT_PUBMED_8674113}} | ||
| - | == | + | ==THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95== |
| - | [[http://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT | + | <StructureSection load='1bfe' size='340' side='right'caption='[[1bfe]], [[Resolution|resolution]] 2.30Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[1bfe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BFE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BFE FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bfe OCA], [https://pdbe.org/1bfe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bfe RCSB], [https://www.ebi.ac.uk/pdbsum/1bfe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bfe ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | < | + | == Function == |
| + | [https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bf/1bfe_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bfe ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Doyle | + | [[Category: Doyle DA]] |
| - | [[Category: Kim | + | [[Category: Kim E]] |
| - | [[Category: Lee | + | [[Category: Lee A]] |
| - | [[Category: Lewis | + | [[Category: Lewis J]] |
| - | [[Category: Mackinnon | + | [[Category: Mackinnon R]] |
| - | [[Category: Sheng | + | [[Category: Sheng M]] |
| - | + | ||
| - | + | ||
Current revision
THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95
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Categories: Large Structures | Rattus norvegicus | Doyle DA | Kim E | Lee A | Lewis J | Mackinnon R | Sheng M
