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1z63

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{{STRUCTURE_1z63| PDB=1z63 | SCENE= }}
 
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===Sulfolobus solfataricus SWI2/SNF2 ATPase core in complex with dsDNA===
 
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{{ABSTRACT_PUBMED_15882619}}
 
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==About this Structure==
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==Sulfolobus solfataricus SWI2/SNF2 ATPase core in complex with dsDNA==
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[[1z63]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z63 OCA].
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<StructureSection load='1z63' size='340' side='right'caption='[[1z63]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1z63]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z63 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z63 OCA], [https://pdbe.org/1z63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z63 RCSB], [https://www.ebi.ac.uk/pdbsum/1z63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z63 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q97XQ7_SACS2 Q97XQ7_SACS2]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z6/1z63_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z63 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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SWI2/SNF2 ATPases remodel chromatin or other DNA:protein complexes by a poorly understood mechanism that involves ATP-dependent DNA translocation and generation of superhelical torsion. Crystal structures of a dsDNA-translocating SWI2/SNF2 ATPase core from Sulfolobus solfataricus reveal two helical SWI2/SNF2 specific subdomains, fused to a DExx box helicase-related ATPase core. Fully base paired duplex DNA binds along a central cleft via both minor groove strands, indicating that SWI2/SNF2 ATPases travel along the dsDNA minor groove without strand separation. A structural switch, linking DNA binding and the active site DExx motif, may account for the stimulation of ATPase activity by dsDNA. Our results suggest that torque in remodeling processes is generated by an ATP-driven screw motion of DNA along the active site cleft. The structures also redefine SWI2/SNF2 functional motifs and uncover unexpected structural correlation of mutations in Cockayne and X-linked mental retardation syndromes.
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==See Also==
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X-ray structures of the Sulfolobus solfataricus SWI2/SNF2 ATPase core and its complex with DNA.,Durr H, Korner C, Muller M, Hickmann V, Hopfner KP Cell. 2005 May 6;121(3):363-73. PMID:15882619<ref>PMID:15882619</ref>
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*[[Helicase|Helicase]]
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:015882619</ref><references group="xtra"/><references/>
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</div>
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[[Category: Atcc 35091]]
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<div class="pdbe-citations 1z63" style="background-color:#fffaf0;"></div>
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[[Category: Duerr, H.]]
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[[Category: Hickmann, V.]]
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==See Also==
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[[Category: Hopfner, K P.]]
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*[[Helicase 3D structures|Helicase 3D structures]]
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[[Category: Koerner, C.]]
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== References ==
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[[Category: Mueller, M.]]
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<references/>
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[[Category: Hydrolase-dna complex complex]]
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__TOC__
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[[Category: Protein-dna complex]]
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Saccharolobus solfataricus]]
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[[Category: Duerr H]]
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[[Category: Hickmann V]]
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[[Category: Hopfner KP]]
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[[Category: Koerner C]]
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[[Category: Mueller M]]

Current revision

Sulfolobus solfataricus SWI2/SNF2 ATPase core in complex with dsDNA

PDB ID 1z63

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