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4hg9

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{{STRUCTURE_4hg9| PDB=4hg9 | SCENE= }}
 
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===Crystal structure of AhV_bPA, a basic PLA2 from Agkistrodon halys pallas venom===
 
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==Function==
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==Crystal structure of AhV_bPA, a basic PLA2 from Agkistrodon halys pallas venom==
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[[http://www.uniprot.org/uniprot/PA2BB_GLOHA PA2BB_GLOHA]] Snake venom phospholipase A2 (PLA2) that shows potent hemolytic activity, and exhibits medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 90 nM). It is one of the few phospholipases A2 capable of hydrolyzing the phospholipids of E.coli membranes in the presence of a bactericidal/permeability-increasing protein (BPI) of neutrophils. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18062812</ref> <ref>PMID:10728829</ref>
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<StructureSection load='4hg9' size='340' side='right'caption='[[4hg9]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4hg9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HG9 FirstGlance]. <br>
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[[4hg9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HG9 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=G3P:SN-GLYCEROL-3-PHOSPHATE'>G3P</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hg9 OCA], [https://pdbe.org/4hg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hg9 RCSB], [https://www.ebi.ac.uk/pdbsum/4hg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hg9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PA2BB_GLOHA PA2BB_GLOHA] Snake venom phospholipase A2 (PLA2) that shows potent hemolytic activity, and exhibits medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 90 nM). It is one of the few phospholipases A2 capable of hydrolyzing the phospholipids of E.coli membranes in the presence of a bactericidal/permeability-increasing protein (BPI) of neutrophils. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18062812</ref> <ref>PMID:10728829</ref>
==See Also==
==See Also==
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*[[Phospholipase A2|Phospholipase A2]]
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Gloydius halys]]
[[Category: Gloydius halys]]
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[[Category: Li, X.]]
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[[Category: Large Structures]]
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[[Category: Niu, L.]]
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[[Category: Li X]]
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[[Category: Teng, M.]]
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[[Category: Niu L]]
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[[Category: Zeng, F.]]
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[[Category: Teng M]]
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[[Category: Alpha-helix]]
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[[Category: Zeng F]]
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[[Category: Glycerophospholipid]]
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[[Category: Hydrolase]]
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[[Category: Venom gland]]
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Current revision

Crystal structure of AhV_bPA, a basic PLA2 from Agkistrodon halys pallas venom

PDB ID 4hg9

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