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4gs8
From Proteopedia
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| - | {{STRUCTURE_4gs8| PDB=4gs8 | SCENE= }} | ||
| - | ===Structure analysis of cysteine free insulin degrading enzyme (ide) with compound bdm43079 [{[(s)-2-(1h-imidazol-4-yl)-1-methylcarbamoyl-ethylcarbamoyl]-methyl}-(3-phenyl-propyl)-amino]-acetic acid=== | ||
| - | == | + | ==Structure analysis of cysteine free insulin degrading enzyme (ide) with compound bdm43079 [{[(s)-2-(1h-imidazol-4-yl)-1-methylcarbamoyl-ethylcarbamoyl]-methyl}-(3-phenyl-propyl)-amino]-acetic acid== |
| - | [[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN | + | <StructureSection load='4gs8' size='340' side='right'caption='[[4gs8]], [[Resolution|resolution]] 2.99Å' scene=''> |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4gs8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GS8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.99Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MGJ:N-(CARBOXYMETHYL)-N-(3-PHENYLPROPYL)GLYCYL-N-METHYL-L-HISTIDINAMIDE'>MGJ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gs8 OCA], [https://pdbe.org/4gs8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gs8 RCSB], [https://www.ebi.ac.uk/pdbsum/4gs8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gs8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[Insulin- | + | *[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | <references | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Deprez | + | [[Category: Large Structures]] |
| - | [[Category: Deprez-Poulain | + | [[Category: Deprez B]] |
| - | [[Category: Guo | + | [[Category: Deprez-Poulain R]] |
| - | [[Category: Tang | + | [[Category: Guo Q]] |
| - | + | [[Category: Tang WJ]] | |
| - | + | ||
Current revision
Structure analysis of cysteine free insulin degrading enzyme (ide) with compound bdm43079 [{[(s)-2-(1h-imidazol-4-yl)-1-methylcarbamoyl-ethylcarbamoyl]-methyl}-(3-phenyl-propyl)-amino]-acetic acid
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