This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4mf2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:26, 1 March 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_4mf2| PDB=4mf2 | SCENE= }}
 
-
===Structure of human DNA polymerase beta complexed with O6MG as the template base in a 1-nucleotide gapped DNA===
 
-
{{ABSTRACT_PUBMED_24694247}}
 
-
==Function==
+
==Structure of human DNA polymerase beta complexed with O6MG as the template base in a 1-nucleotide gapped DNA==
-
[[http://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>
+
<StructureSection load='4mf2' size='340' side='right'caption='[[4mf2]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4mf2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MF2 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6OG:6-O-METHYL+GUANOSINE-5-MONOPHOSPHATE'>6OG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mf2 OCA], [https://pdbe.org/4mf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mf2 RCSB], [https://www.ebi.ac.uk/pdbsum/4mf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mf2 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>
-
==About this Structure==
+
==See Also==
-
[[4mf2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MF2 OCA].
+
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:024694247</ref><references group="xtra"/><references/>
+
__TOC__
-
[[Category: Koag, M C.]]
+
</StructureSection>
-
[[Category: Lee, S.]]
+
[[Category: Homo sapiens]]
-
[[Category: Min, K.]]
+
[[Category: Large Structures]]
-
[[Category: Monzingo, A F.]]
+
[[Category: Koag MC]]
-
[[Category: Dna polymerase]]
+
[[Category: Lee S]]
-
[[Category: Polymerase x family]]
+
[[Category: Min K]]
-
[[Category: Protein-dna complex]]
+
[[Category: Monzingo AF]]
-
[[Category: Transferase-dna complex]]
+

Current revision

Structure of human DNA polymerase beta complexed with O6MG as the template base in a 1-nucleotide gapped DNA

PDB ID 4mf2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4mf2"
Personal tools