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3w63

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{{STRUCTURE_3w63| PDB=3w63 | SCENE= }}
 
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===MamM-CTD 215-293===
 
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{{ABSTRACT_PUBMED_24658343}}
 
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==About this Structure==
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==MamM-CTD 215-293==
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[[3w63]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W63 OCA].
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<StructureSection load='3w63' size='340' side='right'caption='[[3w63]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3w63]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Magnetospirillum_gryphiswaldense_MSR-1 Magnetospirillum gryphiswaldense MSR-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W63 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w63 OCA], [https://pdbe.org/3w63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w63 RCSB], [https://www.ebi.ac.uk/pdbsum/3w63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w63 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MAMM_MAGGM MAMM_MAGGM] Essential for magnetosome formation; required for stable accumulation of MamB (PubMed:22007638). May nucleate iron crystal formation (Probable). Probably binds and transports iron. Binds divalent cations, possibly up to 3 Zn(2+) per dimer in vitro, probably iron in vivo (Probable) (PubMed:30811856). One of 7 genes (mamLQBIEMO) able to induce magnetosome membrane biogenesis; coexpression of mamLQRBIEMO in a deletion of the 17 gene mamAB operon restores magnetosome vesicle formation but not magnetite biosynthesis (PubMed:27286560).<ref>PMID:22007638</ref> <ref>PMID:27286560</ref> <ref>PMID:30811856</ref> <ref>PMID:22007638</ref> <ref>PMID:24658343</ref> <ref>PMID:24819161</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cation diffusion facilitators (CDF) are part of a highly conserved protein family that maintains cellular divalent cation homeostasis in all domains of life. CDF's were shown to be involved in several human diseases, such as Type-II diabetes and neurodegenerative diseases. In this work, we employed a multi-disciplinary approach to study the activation mechanism of the CDF protein family. For this we used MamM, one of the main ion transporters of magnetosomes - bacterial organelles that enable magnetotactic bacteria to orientate along geomagnetic fields. Our results reveal that the cytosolic domain of MamM forms a stable dimer that undergoes distinct conformational changes upon divalent cation binding. MamM conformational change is associated with three metal binding sites that were identified and characterized. Altogether, our results provide a novel auto-regulation mode of action model in which the cytosolic domain's conformational changes upon ligand binding allows the priming of the CDF into its transport mode.
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==Reference==
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Cation diffusion facilitators transport initiation and regulation is mediated by cation induced conformational changes of the cytoplasmic domain.,Zeytuni N, Uebe R, Maes M, Davidov G, Baram M, Raschdorf O, Nadav-Tsubery M, Kolusheva S, Bitton R, Goobes G, Friedler A, Miller Y, Schuler D, Zarivach R PLoS One. 2014 Mar 21;9(3):e92141. doi: 10.1371/journal.pone.0092141. eCollection, 2014. PMID:24658343<ref>PMID:24658343</ref>
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<ref group="xtra">PMID:024658343</ref><references group="xtra"/><references/>
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[[Category: Davidov, G.]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Zarivach, R.]]
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</div>
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[[Category: Zeytuni, N.]]
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<div class="pdbe-citations 3w63" style="background-color:#fffaf0;"></div>
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[[Category: Divalent cation transport]]
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== References ==
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[[Category: Metal ion transport]]
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<references/>
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[[Category: Metal transport]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Magnetospirillum gryphiswaldense MSR-1]]
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[[Category: Davidov G]]
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[[Category: Zarivach R]]
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[[Category: Zeytuni N]]

Current revision

MamM-CTD 215-293

PDB ID 3w63

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