1k0n

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{{STRUCTURE_1k0n| PDB=1k0n | SCENE= }}
 
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===Chloride Intracellular Channel 1 (CLIC1) complexed with glutathione===
 
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{{ABSTRACT_PUBMED_11551966}}
 
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==Function==
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==Chloride Intracellular Channel 1 (CLIC1) complexed with glutathione==
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[[http://www.uniprot.org/uniprot/CLIC1_HUMAN CLIC1_HUMAN]] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.<ref>PMID:9139710</ref> <ref>PMID:10834939</ref> <ref>PMID:11195932</ref> <ref>PMID:11940526</ref> <ref>PMID:11978800</ref> <ref>PMID:11551966</ref> <ref>PMID:14613939</ref>
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<StructureSection load='1k0n' size='340' side='right'caption='[[1k0n]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1k0n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K0N FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k0n OCA], [https://pdbe.org/1k0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k0n RCSB], [https://www.ebi.ac.uk/pdbsum/1k0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k0n ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CLIC1_HUMAN CLIC1_HUMAN] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.<ref>PMID:9139710</ref> <ref>PMID:10834939</ref> <ref>PMID:11195932</ref> <ref>PMID:11940526</ref> <ref>PMID:11978800</ref> <ref>PMID:11551966</ref> <ref>PMID:14613939</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k0/1k0n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k0n ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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[[1k0n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K0N OCA].
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:011551966</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bauskin, A R.]]
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[[Category: Large Structures]]
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[[Category: Breit, S N.]]
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[[Category: Bauskin AR]]
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[[Category: Campbell, T J.]]
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[[Category: Breit SN]]
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[[Category: Curmi, P M.G.]]
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[[Category: Campbell TJ]]
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[[Category: DeMaere, M Z.]]
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[[Category: Curmi PMG]]
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[[Category: Fairlie, W D.]]
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[[Category: DeMaere MZ]]
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[[Category: Harrop, S J.]]
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[[Category: Fairlie WD]]
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[[Category: Jankova, L.]]
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[[Category: Harrop SJ]]
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[[Category: Mazzanti, M.]]
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[[Category: Jankova L]]
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[[Category: Pankhurst, S.]]
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[[Category: Mazzanti M]]
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[[Category: Qiu, M R.]]
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[[Category: Pankhurst S]]
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[[Category: Reztsova, T.]]
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[[Category: Qiu MR]]
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[[Category: Tonini, R.]]
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[[Category: Reztsova T]]
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[[Category: Valenzuela, S M.]]
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[[Category: Tonini R]]
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[[Category: Warton, K.]]
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[[Category: Valenzuela SM]]
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[[Category: Wu, W M.]]
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[[Category: Warton K]]
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[[Category: Chloride ion channel]]
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[[Category: Wu WM]]
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[[Category: Clic1]]
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[[Category: Glutathione]]
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[[Category: Glutathione-s-tranferase superfamily]]
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[[Category: Metal transport]]
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[[Category: Ncc27]]
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Current revision

Chloride Intracellular Channel 1 (CLIC1) complexed with glutathione

PDB ID 1k0n

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