This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ewf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:07, 20 March 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_1ewf| PDB=1ewf | SCENE= }}
 
-
===THE 1.7 ANGSTROM CRYSTAL STRUCTURE OF BPI===
 
-
{{ABSTRACT_PUBMED_10843855}}
 
-
==Function==
+
==THE 1.7 ANGSTROM CRYSTAL STRUCTURE OF BPI==
-
[[http://www.uniprot.org/uniprot/BPI_HUMAN BPI_HUMAN]] The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.<ref>PMID:2722846</ref> <ref>PMID:1937776</ref>
+
<StructureSection load='1ewf' size='340' side='right'caption='[[1ewf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[1ewf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EWF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EWF FirstGlance]. <br>
-
[[1ewf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EWF OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene></td></tr>
-
==Reference==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ewf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ewf OCA], [https://pdbe.org/1ewf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ewf RCSB], [https://www.ebi.ac.uk/pdbsum/1ewf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ewf ProSAT]</span></td></tr>
-
<ref group="xtra">PMID:010843855</ref><references group="xtra"/><references/>
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/BPI_HUMAN BPI_HUMAN] The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.<ref>PMID:2722846</ref> <ref>PMID:1937776</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ew/1ewf_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ewf ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Beamer, L J.]]
+
[[Category: Large Structures]]
-
[[Category: Eisenberg, D.]]
+
[[Category: Beamer LJ]]
-
[[Category: Grothe, R.]]
+
[[Category: Eisenberg D]]
-
[[Category: Kleiger, G.]]
+
[[Category: Grothe R]]
-
[[Category: Mallick, P.]]
+
[[Category: Kleiger G]]
-
[[Category: Antibiotic]]
+
[[Category: Mallick P]]
-
[[Category: Bactericidal]]
+
-
[[Category: Lipid-binding]]
+
-
[[Category: Lipopolysaccharide-binding]]
+
-
[[Category: Permeability-increasing]]
+

Current revision

THE 1.7 ANGSTROM CRYSTAL STRUCTURE OF BPI

PDB ID 1ewf

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ewf"
Personal tools