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2jnz
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="2jnz" size="350" color="white" frame="true" align="right" spinBox="true" caption="2jnz" /> '''Solution structure of phl p 3, a major aller...) |
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| - | [[Image:2jnz.jpg|left|200px]]<br /><applet load="2jnz" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2jnz" /> | ||
| - | '''Solution structure of phl p 3, a major allergen from timothy grass pollen'''<br /> | ||
| - | == | + | ==Solution structure of phl p 3, a major allergen from timothy grass pollen== |
| - | + | <StructureSection load='2jnz' size='340' side='right'caption='[[2jnz]]' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | [[ | + | <table><tr><td colspan='2'>[[2jnz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phleum_pratense Phleum pratense]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JNZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JNZ FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jnz OCA], [https://pdbe.org/2jnz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jnz RCSB], [https://www.ebi.ac.uk/pdbsum/2jnz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jnz ProSAT]</span></td></tr> |
| - | [ | + | </table> |
| - | [[ | + | == Function == |
| - | [[ | + | [https://www.uniprot.org/uniprot/Q69B42_PHLPR Q69B42_PHLPR] |
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jn/2jnz_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jnz ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The major 97-aa timothy grass (Phleum pratense) allergen Phl p 3 was recently isolated from an extract of timothy grass pollen. Sequence comparison classifies this protein as a group 3 allergen. The solution structure of Phl p 3 as determined by nuclear magnetic resonance spectroscopy reveals that the protein consists of a core of hydrophobic amino-acid side chains from two beta-sheets of five and four anti-parallel beta-strands, respectively. This conformation is very similar to the crystal structure published for Phl p 2 and strongly resembles the known conformation of the carboxy-terminal domain of Phl p 1, the major difference being the loop orientations. Phl p 2 and Phl p 3 show virtually identical immunoreactivity, and comparison of the charged surface amino acids of the two proteins gives initial clues as to the IgE recognition epitopes of these proteins. | ||
| - | + | Solution structure of Phl p 3, a major allergen from timothy grass pollen.,Schweimer K, Petersen A, Suck R, Becker WM, Rosch P, Matecko I Biol Chem. 2008 Jul;389(7):919-23. PMID:18627309<ref>PMID:18627309</ref> | |
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 2jnz" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Phleum pratense]] | ||
| + | [[Category: Matecko I]] | ||
| + | [[Category: Roesch P]] | ||
| + | [[Category: Schweimer K]] | ||
Current revision
Solution structure of phl p 3, a major allergen from timothy grass pollen
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