1ntl

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{{STRUCTURE_1ntl| PDB=1ntl | SCENE= }}
 
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===Model of mouse Crry-Ig determined by solution scattering, curve fitting and homology modelling===
 
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{{ABSTRACT_PUBMED_12767833}}
 
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==Function==
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==Model of mouse Crry-Ig determined by solution scattering, curve fitting and homology modelling==
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[[http://www.uniprot.org/uniprot/CR1L_MOUSE CR1L_MOUSE]] Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion.<ref>PMID:1730912</ref> <ref>PMID:7528766</ref> <ref>PMID:10779754</ref> <ref>PMID:10642554</ref> <ref>PMID:11986227</ref>
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<StructureSection load='1ntl' size='340' side='right'caption='[[1ntl]], [[Resolution|resolution]] 30.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1ntl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NTL FirstGlance]. <br>
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[[1ntl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTL OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray solution scattering, [[Resolution|Resolution]] 30&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ntl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ntl OCA], [https://pdbe.org/1ntl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ntl RCSB], [https://www.ebi.ac.uk/pdbsum/1ntl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ntl ProSAT]</span></td></tr>
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==Reference==
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</table>
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<ref group="xtra">PMID:012767833</ref><references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/IGHG1_MOUSE IGHG1_MOUSE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/1ntl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ntl ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Aslam, M.]]
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[[Category: Aslam M]]
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[[Category: Guthridge, J M.]]
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[[Category: Guthridge JM]]
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[[Category: Hack, B K.]]
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[[Category: Hack BK]]
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[[Category: Holers, V M.]]
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[[Category: Holers VM]]
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[[Category: Perkins, S J.]]
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[[Category: Perkins SJ]]
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[[Category: Quigg, R J.]]
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[[Category: Quigg RJ]]
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[[Category: Ccp]]
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[[Category: Complement]]
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[[Category: Glycoprotein]]
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[[Category: Immune system]]
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[[Category: Immunology]]
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[[Category: Scr]]
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Current revision

Model of mouse Crry-Ig determined by solution scattering, curve fitting and homology modelling

PDB ID 1ntl

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