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1jpv

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{{STRUCTURE_1jpv| PDB=1jpv | SCENE= }}
 
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===Crystal Structure of 5'-deoxy-5'-methylthioadenosine phosphorylase complexed with SO4===
 
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{{ABSTRACT_PUBMED_11489901}}
 
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==Function==
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==Crystal Structure of 5'-deoxy-5'-methylthioadenosine phosphorylase complexed with SO4==
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[[http://www.uniprot.org/uniprot/MTAP_SULSO MTAP_SULSO]] Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.<ref>PMID:15819883</ref>
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<StructureSection load='1jpv' size='340' side='right'caption='[[1jpv]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1jpv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JPV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jpv OCA], [https://pdbe.org/1jpv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jpv RCSB], [https://www.ebi.ac.uk/pdbsum/1jpv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jpv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PNPH_SACS2 PNPH_SACS2] Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules. Cleaves inosine, guanosine, and adenosine with a better efficiency than MTA.<ref>PMID:15819883</ref> <ref>PMID:7929153</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jp/1jpv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jpv ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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[[1jpv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPV OCA].
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*[[5'-deoxy-5'-methylthioadenosine phosphorylase 3D structures|5'-deoxy-5'-methylthioadenosine phosphorylase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:011489901</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: S-methyl-5'-thioadenosine phosphorylase]]
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</StructureSection>
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[[Category: Sulfolobus solfataricus]]
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[[Category: Large Structures]]
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[[Category: Appleby, T C.]]
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[[Category: Saccharolobus solfataricus]]
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[[Category: Cacciapuoti, G.]]
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[[Category: Appleby TC]]
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[[Category: Ealick, S E.]]
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[[Category: Cacciapuoti G]]
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[[Category: Mathews, I I.]]
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[[Category: Ealick SE]]
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[[Category: Porcelli, M.]]
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[[Category: Mathews II]]
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[[Category: Alpha-beta protein]]
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[[Category: Porcelli M]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of 5'-deoxy-5'-methylthioadenosine phosphorylase complexed with SO4

PDB ID 1jpv

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