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1ri1
From Proteopedia
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| - | {{STRUCTURE_1ri1| PDB=1ri1 | SCENE= }} | ||
| - | ===Structure and mechanism of mRNA cap (guanine N-7) methyltransferase=== | ||
| - | {{ABSTRACT_PUBMED_14731396}} | ||
| - | == | + | ==Structure and mechanism of mRNA cap (guanine N-7) methyltransferase== |
| - | [[ | + | <StructureSection load='1ri1' size='340' side='right'caption='[[1ri1]], [[Resolution|resolution]] 2.50Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[1ri1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Encephalitozoon_cuniculi Encephalitozoon cuniculi]. The January 2012 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Messenger RNA Capping'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2012_1 10.2210/rcsb_pdb/mom_2012_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RI1 FirstGlance]. <br> |
| - | [[1ri1]] is a 1 chain structure with sequence from [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTG:7-METHYL-GUANOSINE-5-TRIPHOSPHATE-5-GUANOSINE'>GTG</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ri1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ri1 OCA], [https://pdbe.org/1ri1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ri1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ri1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ri1 ProSAT]</span></td></tr> |
| - | < | + | </table> |
| - | [[Category: | + | == Function == |
| + | [https://www.uniprot.org/uniprot/MCES_ENCCU MCES_ENCCU] mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.<ref>PMID:15760890</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ri/1ri1_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ri1 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Encephalitozoon cuniculi]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Messenger RNA Capping]] | [[Category: Messenger RNA Capping]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
| - | [[Category: Fabrega | + | [[Category: Fabrega C]] |
| - | [[Category: Hausmann | + | [[Category: Hausmann S]] |
| - | [[Category: Lima | + | [[Category: Lima CD]] |
| - | [[Category: Shen | + | [[Category: Shen V]] |
| - | [[Category: Shuman | + | [[Category: Shuman S]] |
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Current revision
Structure and mechanism of mRNA cap (guanine N-7) methyltransferase
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