1nf8

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{{STRUCTURE_1nf8| PDB=1nf8 | SCENE= }}
 
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===Crystal structure of PhzD protein active site mutant with substrate===
 
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{{ABSTRACT_PUBMED_12741825}}
 
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==About this Structure==
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==Crystal structure of PhzD protein active site mutant with substrate==
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[[1nf8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NF8 OCA].
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<StructureSection load='1nf8' size='340' side='right'caption='[[1nf8]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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==Reference==
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<table><tr><td colspan='2'>[[1nf8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NF8 FirstGlance]. <br>
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<ref group="xtra">PMID:012741825</ref><references group="xtra"/><references/>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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[[Category: Isochorismatase]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=ISC:(5S,6S)-5-[(1-CARBOXYETHENYL)OXY]-6-HYDROXYCYCLOHEXA-1,3-DIENE-1-CARBOXYLIC+ACID'>ISC</scene></td></tr>
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[[Category: Calabrese, K.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nf8 OCA], [https://pdbe.org/1nf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nf8 RCSB], [https://www.ebi.ac.uk/pdbsum/1nf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nf8 ProSAT]</span></td></tr>
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[[Category: Eisenstein, E.]]
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</table>
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[[Category: Ladner, J E.]]
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== Function ==
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[[Category: Parsons, F.]]
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[https://www.uniprot.org/uniprot/PHZD1_PSEAE PHZD1_PSEAE] Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzD1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth (PubMed:23129634). Catalyzes the hydrolysis of the vinyl ether functional group of 2-amino-2-deoxyisochorismate (ADIC), yielding pyruvate and trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA) (PubMed:12741825, PubMed:23129634). Also able to act on isochorismate, chorismate and 4-amino-4-deoxychorismate (ADC) as substrates (PubMed:12741825).<ref>PMID:12741825</ref> <ref>PMID:23129634</ref> <ref>PMID:11591691</ref>
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[[Category: Enzyme]]
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== Evolutionary Conservation ==
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[[Category: Hydrolase]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Isochorismatase]]
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Check<jmol>
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[[Category: Phenazine pathway]]
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nf/1nf8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nf8 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Pseudomonas aeruginosa]]
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[[Category: Calabrese K]]
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[[Category: Eisenstein E]]
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[[Category: Ladner JE]]
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[[Category: Parsons F]]

Current revision

Crystal structure of PhzD protein active site mutant with substrate

PDB ID 1nf8

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